ProDeg™ HG-7-85-01, Target protein ligand (Protein Degrader) (CAT#: PRLG-012)
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Datasheets
| Specifications |
|---|
| Product Description |
HG-7-85-01 is a type II kinase inhibitor targeting BCR-ABL that binds to the DFG-out conformation of the kinase domain. Its high affinity and specificity support its use as a recognition moiety in bifunctional chemical agents. |
| Molecular Formula |
C31H31F3N6O2S |
| Molecular Weight (Da) |
608.7 |
| Chemical Name |
3-[2-(cyclopropanecarbonylamino)-[1,3]thiazolo[5,4-b]pyridin-5-yl]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
ABL1 |
| Alternative Names |
ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl |
| Introduction |
ABL1 is a non-receptor tyrosine kinase containing an SH3 domain, an SH2 domain, and a C-terminal kinase domain. It localizes to both the cytoplasm and nucleus, where it regulates cell proliferation, cytoskeletal dynamics, and DNA damage responses. |
| Gene ID |
25 |
| UniProt ID |
P00519 |
| Related Disease |
Chronic myeloid leukemia, acute lymphoblastic leukemia, gastrointestinal stromal tumor |
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