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Datasheets
| Specifications | |
|---|---|
| Product Description | Thalidomide linker 1 is thalidomide-PEG3-ethylamine. This synthesized compound incorporates a cereblon E3 ligase ligand and a PEG linker ready for conjugation to a target protein ligand. |
| Molecular Formula | C₂₃H₃₀N₄O₉ ∙ HCl |
| Molecular Weight (Da) | 542.97 |
| Chemical Name | N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride |
| Purity | 95% |
| Solubility | 50 mg/mL in DMSO; 50 mg/mL in water |
| Size | 10 mg |
| Physical State | Lyophilized white powder |
| Storage | Stored at -20°C. |
| Target Information | |
|---|---|
| Target Name | Cereblon |
| Alternative Names | CRBN; MRT2; MRT2A |
| Introduction | Cereblon is the substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex. The complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Gene ID | 51185 |
| UniProt ID | Q96SW2 |
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