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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human SIAH1 protein, Fc Tag |
| Alternative Names | BURHAS; SIAH1A |
| Gene Name | SIAH1 |
| Species | Human |
| Introduction | Seven in absentia homolog 1 (SIAH1) is an E3 ligase with a RING finger domain and a substrate-binding domain that recognizes degron motifs containing a VxP motif. It forms homodimers via its RING domain. |
| Function | SIAH1 is a highly conserved RING-finger E3 ligase that responds directly to cellular stress. In proximity-induced destruction programs, SIAH1 recruitment offers an intriguing mechanism due to its ability to recognize diverse amphipathic peptide sequences, allowing bifunctional molecules to bridge and clear previously untargetable cytoplasmic factors. |
| Related Disease | Breast cancer, HCC, leukemias (tumor-promoting role) |
| Gene ID | 6477 |
| UniProt ID | Q8IUQ4 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 282 |
| Molecular Weight (kDa) | 34.6 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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