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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human UHRF1 protein, Fc Tag |
| Alternative Names | Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95 |
| Gene Name | UHRF1 |
| Species | Human |
| Introduction | Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contains a ubiquitin-like domain, a PHD finger, a SET and RING-associated (SRA) domain, and a RING finger. |
| Function | UHRF1 is a multi-domain epigenetic E3 ligase that acts as a master regulator of DNA methylation fidelity. In proximity-induced therapeutic design, hijacking UHRF1 offers an exceptional avenue for deleting aberrant chromatin-remodeling factors, bridging epigenetic recognition directly with targeted proteasomal destruction. |
| Related Disease | Soft tissue sarcoma, oral squamous cell carcinoma (OSCC), melanoma, retinoblastoma, lung adenocarcinoma, osteosarcoma, HCC (overexpression, oncogenic driver) |
| Gene ID | 29128 |
| UniProt ID | Q96T88 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 806 |
| Molecular Weight (kDa) | 90 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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