Recombinant Human UHRF1 protein, Fc Tag (CAT#: PRLP-035)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human UHRF1 protein, Fc Tag |
| Alternative Names |
Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95 |
| Gene Name |
UHRF1 |
| Species |
Human |
| Introduction |
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contains a ubiquitin-like domain, a PHD finger, a SET and RING-associated (SRA) domain, and a RING finger. |
| Function |
UHRF1 is a multi-domain epigenetic E3 ligase that acts as a master regulator of DNA methylation fidelity. In proximity-induced therapeutic design, hijacking UHRF1 offers an exceptional avenue for deleting aberrant chromatin-remodeling factors, bridging epigenetic recognition directly with targeted proteasomal destruction. |
| Related Disease |
Soft tissue sarcoma, oral squamous cell carcinoma (OSCC), melanoma, retinoblastoma, lung adenocarcinoma, osteosarcoma, HCC (overexpression, oncogenic driver) |
| Gene ID |
29128 |
| UniProt ID |
Q96T88 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
806 |
| Molecular Weight (kDa) |
90 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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