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Datasheets
| Specifications | |
|---|---|
| Product Description | VH032 is a potent VHL ligand that binds to the substrate-binding pocket of VHL with high affinity, mimicking the HIF-1alpha hydroxyproline motif. It is the most widely used warhead for VHL-recruiting bifunctional chemical agents. |
| Molecular Formula | C24H32N4O4S |
| Molecular Weight (Da) | 472.6 |
| Chemical Name | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | VHL |
| Alternative Names | HRCA1, RCA1, VHL1, pVHL |
| Introduction | VHL is the substrate recognition subunit of the CUL2-RBX1-Elongin B/C E3 ubiquitin ligase complex, containing a beta-domain that binds HIF-alpha and an alpha-domain that interacts with Elongin C. It is a tumor suppressor frequently mutated in von Hippel-Lindau disease. |
| Gene ID | 7428 |
| UniProt ID | P40337 |
| Related Disease | Von Hippel-Lindau disease, renal cell carcinoma, hemangioblastoma, pheochromocytoma |
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