Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNALCN channel complex family is composed of G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and Src family tyrosine kinases. It is a voltage-independent and cation-nonselective channel complex mainly expressed in the nervous system. NALCN complex can transport sodium leaky across the neuronal membranes and mediate neuronal excitability. Studies have shown that NALCN complex is involved in many biological processes including locomotor behaviors, rhythms behaviors, and sensitivity to volatile anesthetics. Moreover, mutations in NALCN gene are associated with infantile neuroaxonal dystrophy (INAD), autosomal recessive syndrome with severe hypotonia, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. UNC-79 and UNC-80 proteins may be linked to the progression of several mental disorders, such as schizophrenia, autism, epilepsy, and alcoholism.
Here show components of NALCN channel complex in humans. UNC79 indirectly connects to NALCN through a constructed bridge by UNC80, which is very important for the stable and functional NALCN channel complex.
| Human components of NALCN channel complex | |
| UNC79 | UNC80 |
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
