Introduction of PTGFR
PTGFR, also known as Prostaglandin F receptor (FP), is a receptor belonging to the prostaglandin (PG) group of receptors. PTGFR binds to and mediates the biological actions of Prostaglandin F2α (PGF2α). It is encoded by the PTGFR gene in humans. PTGFR is expressed as two alternatively spliced transcript variants encoding different isoforms, FPA and FPB, which have different C-terminal lengths. In certain cells, activation of PTGFR also stimulates G12/G13-Gβγ G proteins to activate the Rho family of GTPases signaling proteins and Gi-Gβγ G proteins to activate Raf/MEK/mitogen-activated kinase pathways.
|Basic Information of PTGFR|
|Protein Name||Prostaglandin F2-alpha receptor|
|Aliases||Prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, Prostanoid FP receptor|
|Organism||Homo sapiens (Human)|
Function of PTGFR Membrane Protein
This PTGFR receptor serves a variety of functions. It has been regarded as the most successful therapeutic target among the 9 prostanoid receptors. One side effect of applying PTGFR receptor agonists to eyelashes in humans is the development of hyperpigmentation at nearby skin sites. Studies have suggested that PTGFR receptor activation may be a useful means to increase skin pigmentation. Besides, PGF2α causes airway constriction in normal and asthmatic humans and its presence in human sputum is related to sputum eosinophil levels. Thus, activation of PTGFR has pathophysiological consequences for the cardiovascular system relative to blood pressure, cardiac function, and atherosclerosis in animal models.
Fig.1 Structure of PTGFR membrane protein.
Application of PTGFR Membrane Protein in Literature
The article indicates that rs12731181 in the seed region of the miR-590-3p target site is associated with an increased risk of essential hypertension and represents a new paradigm for FP involvement in blood pressure regulation.
This article suggests that the role of the PTGFR in the human uterus requires further validation prior to pursuing it as a target for the treatment of preterm labor.
The article reveals that prostaglandin F(2alpha) can directly regulate endothelial cell network formation but not endothelial cell proliferation.
The article proposes for the first time that human umbilical vein express prostanoid FP-receptors and these receptors could be involved in the vasoconstriction action of PGF(2alpha) in this tissue.
The article concludes that an association was found between SNPs of the FP receptor gene and the response to latanoprost in patients with glaucoma or OH. The FP receptor genetic polymorphism may influence the degree of IOP reduction by latanoprost in these patients.
PTGFR Preparation Options
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