Introduction of PTH2R
PTH2R (Parathyroid hormone 2 receptor), also known as PTH2 receptor, is a protein encoded by the PTH2R gene in humans. The protein encoded by this gene is a member of the G protein-coupled receptor family 2. PTH2R is a receptor for parathyroid hormone. The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.
|Basic Information of PTH2R|
|Protein Name||Parathyroid hormone 2 receptor|
|Aliases||Parathyroid hormone 2 receptor, PTH2 receptor|
|Organism||Homo sapiens (Human)|
Function of PTH2R Membrane Protein
As a receptor for parathyroid hormone (PTH), PTH2R is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas. Moreover, some studies suggested that PTH2R is involved in the regulation of viscerosensory information processing. In addition, variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine.
Fig.1 Structure of PTH2R membrane protein.
Application of PTH2R Membrane Protein in Literature
The article concludes that PTH2 receptor is expressed on human granulocytes and--to a lesser degree--on monocytes and lymphocytes. In patients with hyperparathyroidism, the PTH2 receptor is down-regulated as function of plasma PTH levels.
The article reveals that independent demonstration of the presence of PTH2R mRNA and immunoreactivity supports the specific expression of the PTH2R in the human brainstem.
The article explores the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. And variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine.
The article reports PTH2R as a gene that is disrupted in NSC. The disruption of the PTH2R gene may cause uncontrolled proliferation and differentiation of chondrocytes, which in turn results in premature closure of sutures.
The article indicates that high affinity binding of the peptide agonist TIP-39 to the PTH2 receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.
PTH2R Preparation Options
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