Receptor Activity Modification Protein 1 (RAMP1) is a protein encoded by RAMP1 gene in humans. It is a member of the RAMP family, which are also known as single-transmembrane domain proteins called receptor (calcitonin) activity-modifying proteins (RAMPs). RAMP1 is a type I transmembrane protein consist of an extracellular N-terminus and a cytoplasmic C-terminus.
|Basic Information of RAMP1|
|Protein Name||Receptor activity-modifying protein 1|
|Aliases||Calcitonin-receptor-like receptor activity-modifying protein 1 (CRLR activity-modifying protein 1)|
|Organism||Homo sapiens (Human)|
RAMP1 is required to transport the calciton receptor-receptor (CALCRL) onto the plasma membrane. CALCRL is a receptor with seven transmembrane domains that can act as a calcitonin gene-related peptide (CGRP) receptor or adrenergic receptor, depending on how members of the slope family are expressed. In combination with RAMP proteins, CALCRL acts as a CGRP receptor. RAMPs have been shown to interact with g-protein-coupled receptors such as the calcitonin receptor, vasoactive intestinal peptide receptor (VIPR), calcitonin receptor, calcium-sensing receptor, parathyroid hormone receptor, high Glucagon receptor and corticotropin releasing factor receptor 1 to regulate their trafficking, pharmacological properties and signaling capabilities.
Fig.1 The structure of Receptor activity-modifying protein 1.
This article shows that the interface of the ramp-receptor is pharmacologically treatable, suggesting that it may be possible to develop compounds directed to the RAMP1/CLR interface to aid in the treatment of asthma.
These data provide new insights into the role of RAMP1 in promoting prostate tumorigenesis and support the possibility of being a new biomarker and a potential therapeutic target in prostate cancer.
This study provides the first evidence that DNA methylation of RAMP1 promoters may play a role in migraine.
These results demonstrate the co-evolution of global GPCRs and RAMPs and support the hypothesis that GPCRs interact globally with RAMPs on cellular signaling pathways.
This review covers recent discoveries in the field of RAMPs and summarizes the capabilities of known GPCR partners and RAMPs.
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