Receptor activity-modifying proteins (RAMP) are a group of membrane-spanning accessory proteins that interact with and modulate the functions of several Class B G protein-coupled receptors (GPCRs) such as the receptors for secretin, glucagon, calcitonin (CT), and vasoactive intestinal peptide (VIP). RAMPs form a small family of 3 (in mammals) distinct types of proteins, referred to as RAMP1, RAMP2, and RAMP3, each encoded by a separate gene. They have a substantial capacity for introducing functional diversity by interacting with GPCRs. RAMPs are suggested to modulate trafficking, signaling, and pharmacology in a receptor-dependent manner. RAMPs may function in an allosteric manner to generate a spectrum of unique calcitonin receptor conformational states, explaining the pharmacological preferences of calcitonin receptor-RAMP complexes.
GPCRs are very important cell surface signaling proteins which are responsible for controlling numerous physiological processes and have been regarded as the targets for ~30% of all medications. The interaction of RAMPs with GPCRs is considered to be significant since they provide an efficient way of controlling their function and may provide further opportunities for drug development. Below are the three RAMPs in human that you may be interested in.
Based on our Magic™ membrane protein production platform, scientists at Creative Biolabs are experts in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.
In addition, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.