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HighlightsBlood group Rh(D) polypeptide (RHD), also known as Rh blood group D antigen, Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D), is a protein that in humans is encoded by the RHD gene. The RH locus is composed of the RHD and RHCE genes, which share a high level of the homology and are organized in tandem on chromosome 1p34-p36. RHD polypeptide is predicted to contain 11 hydrophobic transmembrane (TM) domains.
| Basic Information of RHD | |
| Protein Name | Blood group Rh(D) polypeptide |
| Gene Name | RHD |
| Aliases | RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD_antigen: CD240D |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q02161 |
| Transmembrane Times | 11 |
| Length (aa) | 417 |
| Sequence | MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIGFQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF |
RH blood group system is one of the important blood groups that are important in transfusion and clinical medicine because of the involvement in the hemolytic disease of the newborn, transfusion reactions, autoimmune hemolytic anemias, and hemolytic reactions of nonimmune origin. As an important polypeptide of RH blood system, RHD antigen determines the subtype of Rh-positive and Rh-negative according to its presence or absence on the surface of erythrocytes. In addition, RHD may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. There are several nonerythroid homologues of RHD have been identified (RhBG and RhCG), notably in diverse organs specialized in ammonia production and excretion, such as kidney, liver, and intestine.
Fig.1 Molecular structure of RhCG. (Gruswitz, 2010)
This article studied ABO and RhD blood group distribution in nasal polyposis (NP) patients and found that the ABO and RhD blood group systems are not associated with the development of NP.
This article reported the molecular bases of D antigen negativity in the D-, C/E+ Indian population firstly, which appeared to be qualitatively similar to other populations, but with a population-specific, quantitative distribution of D- alleles.
This study suggested that the biosensor techniques could become an alternative part of fetal RHD genotyping from maternal plasma as a prenatal screening in the management of RhD incompatibility.
This article showed that performing RHD genotyping for pregnant women with a weak D phenotype enabled to clearly identify weak D type 1, 2 or 3 from other variants at risk of alloimmunization. This analysis generated savings in terms of follow-up schedule of pregnant women and RhIG prophylaxis.
This study demonstrated that foetal RHD detection on maternal plasma using a commercial multiple-exon assay was a reliable and accurate tool to predict foetal RhD phenotype. It could be a safe guide for the appropriate administration of targeted prenatal immunoprophylaxis.
We provide custom membrane protein preparation services for worldwide customers. Leveraging by our advanced Magic™ membrane protein production platform, we are able to present target membrane protein in multiple active formats. Our professional scientists are happy to help you find an ideal method and make your project a success. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-RHD antibody development services.
Creative Biolabs provides high-quality membrane protein preparation service to facilitate the development of worldwide customer’s research. During the past years, we have successfully established a powerful Magic™ membrane protein platform which enables us to provide a series of membrane protein preparation services. For more detailed information, please feel free to contact us.
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