Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsImmunogenicity testing is an important part of the clinical safety assessment of biotech drugs. Drug-induced antibody responses can affect pharmacokinetics, pharmacodynamics, and toxicity. The immunogenicity may be a chimeric biopharmaceutical, or even a humanized molecule and a fully-humanized biopharmaceutical drug. In most cases, immunogenicity is caused by residues in the CDR regions. Creative Biolabs provides you with detailed testing methods and testing techniques in ADA assay sample test and accurate analysis of your samples, in order to enter the clinical trials more quickly, to ensure the safety of a candidate drug.
Screening assays and specificity assays are typically included, and characterization assays typically include antibody titration and neutralization antibody detection. When applied to a specific study sample, the anti-drug antibody analysis experiment requires two key decision parameters, which are the screening critical point of the screening test and the specific critical point of the specific verification test. The screening critical point contributes to the classification of the anti-drug antibody detection results, the active sample is higher than the screening critical point, and the inactive sample is below the critical point. The active sample is tested positive or negative by a specific confirmation test. The specificity critical point is the amount of sample required to suppress signal passage, that is, the drug-resistant antibody of a specific drug, which needs to be determined by experiments.
Fig.1 ADA assay formats used for cynomolgus monkeys. (Carrasco-Triguero, 2016)
Validation tests prior to the start of sample bioanalysis in clinical and non-clinical studies are usually known as pre-study validation, which describes the performance characteristics of analytical methods in terms of both mathematical and quantifiable aspects. After a complete method of development and optimization, the analytical method should be qualified for the corresponding verification. For example, the optimized experimental data indicates that the detection method has potential reliability and is suitable for the corresponding testing requirements.
Creative Biolabs owns the most comprehensive testing equipment and testing technology. Please contact us in time about more details and we will be glad to serve you.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
