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Single Domain Antibody Conjugation Services

Creative Biolabs is a leader in the field of antibody and antibody fragments conjugation, especially the single domain antibody (sdAb) conjugation. We have developed a range of custom sdAb bioconjugation services, including quantum dots conjugation, fluorophores conjugation, PEGylation conjugation, biotins conjugation and so on. We also offer customize bioconjugation service to meet our clients’ specific research programs.

Bioconjugation is a chemical strategy to form a stable covalent link between two molecules. Synthetically modified biomolecules can have diverse functionalities, such as tracking cellular actions, revealing enzyme function, determining protein biodistribution, and specific biomarkers. The common bioconjugations are coupling of a small molecule, such as biotin or fluorescent dye, to antibodies, or protein-protein conjugations, such as the coupling of an antibody to an enzyme. Moreover, antibodies conjugated to oligosaccharides, nucleic acids, and synthetic polymers are widely used in pharmaceutical industry.

Single Domain Antibody Conjugation Services Fig. 1 QD-VHH conjugation (Sukhanova A et al. 2012).

Single domain antibodies (sdAbs) are antibody fragment consisting of a single monomeric variable antibody domain, derived from the heavy-chain-only antibodies produced by camelids or sharks, or the specific developed human VH and VL domain. Compared to conventional antibodies, sdAb has advantages that cannot be ignored. The fusion of biological molecular to sdAb targeting proteins allows nanometer spatial resolution and minimal linkage error because of the small size and high affinity of sdAb. Therefore, conjugated sdAbs have been found significant applications for enhanced stability, sensitive and functionalities in diagnostics and therapeutics.

Single Domain Antibody Conjugation Services Fig.2 SdAb Conjugation.

Typical services

Our extensive range of custom sdAb conjugation service including but not limited to:

Table 1. Hot Services of SdAb Conjugation

The applications of sdAb conjugation services including but not limited to:

Benefits of sdAb conjugation service:

Based on our deep knowledge and rich experience in biomaterial conjugation, Creative Biolabs offers advanced processes for various sdAb conjugation services. Our services can be tailored to meet our customers’ unique requirements under a fast, reliable and affordable manner. If you are interested in our sdAb conjugation service, please feel free to inquire us to for more details.


  1. Sukhanova, A.; et al. Oriented conjugates of monoclonal and single-domain antibodies with quantum dots for flow cytometry and immunohistochemistry diagnostic applications. Proc. SPIE. 2012, 8232: 82320T.

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