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HighlightsSolute carrier family 11 member 2 (SLC11A2), also known as divalent metal transporter 1 (DMT1) or divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 gene. SLC11A2 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans. SLC11A2 can bind with a variety of divalent metals including cadmium (Cd2+), copper (Cu2+), and zinc (Zn2+), and it is best known for its role in transporting ferrous iron (Fe2+). SLC11A2 expression is regulated by body iron stores to maintain iron homeostasis. SLC11A2 is also important in the absorption and transport of manganese (Mn2+). It is located on the apical membrane of enterocytes in digestive tract, where it carries out H+ coupled transport of divalent metal cations from the intestinal lumen into the cell.
| Basic Information of SLC11A2 | |
| Protein Name | Natural resistance-associated macrophage protein 2 |
| Gene Name | SLC11A2 |
| Aliases | Divalent cation transporter 1, Divalent metal transporter 1(DMT-1), Solute carrier family 11 member 2 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P49281 |
| Transmembrane Times | 12 |
| Length (aa) | 568 |
| Sequence | MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR |
Toxic accumulation of divalent metal has an influence on a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. SLC11A2 is the major transporter of manganese across the blood brain barrier. This protein in the nasal epithelium provides a route for direct absorption of metals into the brain. SLC11A2 expression in the brain may increase with age, increasing susceptibility to metal-induced pathologies. SLC11A2 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.
The authors inactivate the murine gene that encodes SLC11A2. The fetal Slc11a2 is not necessary for materno-fetal iron transfer but that Slc11a2 activity is essential for intestinal non-heme iron absorption after birth. Slc11a2 is also required for normal hemoglobin production during the development of erythroid precursors.
This article indicates that alternative splicing of DMT1 exerts a role in the regulation of the subcellular localization and site of Fe(2+) transport.
In this article, authors propose that DMT1(C1246T) (R416C) displays a complete loss-of-function, and the decreased DMT1 expression may lead to the microcytic anemia and iron overload in the patient.
In this article, authors hypothesize that the iron uptake activity of DMT1 in the patient's erythroid cells is severely inhibited because of the quantitative reduction of DMT1.
Membrane protein studies have got great progress over the past few years. Based on our versatile Magic™ membrane protein production platform, we can provide a series of membrane protein preparation services in reconstitution forms as well as multiple active formats for worldwide customers. Besides, aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC11A2 antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. It's our pleasure to boost the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.
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