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HighlightsSolute carrier family 16 member 7 (SLC16A7), also known as monocarboxylate transporter 2 (MCT2), is encoded by the gene SLC16A7. It is a member of the monocarboxylate transporter family. SLC16A7 is a proton-coupled monocarboxylate transporter, which is mainly found in cells with low monoacid concentration, such as renal tubules, nerve cells, and sperm tail. Among the MCT family, MCT2 (SLC16A7) has the highest affinity for lactic acid. In parallel, SLC16A7 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.
| Basic Information of SLC16A7 | |
| Protein Name | Monocarboxylate transporter 2 |
| Gene Name | SLC16A7 |
| Aliases | Solute carrier family 16 member 7 |
| Organism | Homo sapiens (Human) |
| UniProt ID | O60669 |
| Transmembrane Times | 12 |
| Length (aa) | 478 |
| Sequence | MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI |
The MCT family can promote nutrient absorption, affect metabolic dynamic balance, regulate cell pH and participate in drug delivery. For SLC16A7, it is mainly responsible for the transport of lactic acid and is only expressed in the small intestine. In the process of transporting protons and monocarboxylic acids, H+ binds to MCT firstly, then it binds to monocarboxylate anion and transports through the cell membrane in the same direction, and then releases in reverse order. SLC16A7 is often highly expressed during cell carcinogenesis. High expression of SLC16A7 may be associated with the clinical stage of breast cancer, tumor size, axillary lymph node metastasis, and tumor differentiation, and plays an important role in the occurrence and development of breast cancer. MCT2 was also overexpressed in prostate cancer, and selective methylation of MCT2 promoter in cells was repeated.
Fig.1 The relationship between breast cancer cells and fat cells and MCT2 in the microenvironment of breast tissue.
This article shows that glucose-derived lactate is locally produced following neuronal activation, and its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex.
This article reveals that adipocytes promote malignancy of MCT2-expressing breast cancer via β-hydroxybutyrate potentially by inducing the epigenetic upregulation of tumor-promoting genes.
The authors find that actate transport via MCT2 in the cerebellum may play an important role in motor performance and exercises can increase MCT2 expression at the transcriptional level.
Studies in this article have shown that selective demethylation of SLC16A7 / MCT2 promoter occurs in prostate cancer. MCT2 knock-down attenuates the growth of prostate cancer cells and is likely to disrupt the metabolic balance at peroxisomes with implications for the proliferation rates of PCa cells and the activation of oncogenic pathways in PCa linked with the EMT process.
The authors demonstrate that MCT2 is mainly located in peroxisomes in prostate cancer cells and interacts with Pex19 to utilize peroxidase transporters.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC16A7 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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