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HighlightsSolute carrier family 16 member 9 (SLC16A9), also known as monocarboxylate transporter 9 (MCT9), is encoded by SLC16A9 gene. SLC16A9 belongs to the monocarboxylate transporter family and is ubiquitously expressed in the body, especially in the kidney with a high level. The function of SLC16A9 is not clearly known, but SLC16A9 has a close relationship with serum uric acid. It is a member of the solute-carrier transporter family that is expressed in several urate-excreting organs, including intestine and kidney.
| Basic Information of SLC16A9 | |
| Protein Name | Monocarboxylate transporter 9 |
| Gene Name | SLC16A9 |
| Aliases | Solute carrier family 16 member 9 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q7RTY1 |
| Transmembrane Times | 12 |
| Length (aa) | 509 |
| Sequence | MELKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINILDKSYSSEEKCRITLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASN |
The single nucleotide polymorphism (SNP) of SLC16A9 gene is closely related to human blood uric acid levels, and when SLC16A9 amino acid K258T is mutated, the incidence of renal overload gout is significantly higher, suggesting a possible correlation of SLC16A9 in the extra-renal uric acid excretion pathway. The uric acid excretion process of SLC16A9 in intestinal epithelial cells has also been confirmed to be associated with K258T mutant. In addition, a missense variant of SLC16A9, rs2242206, can significantly increase the risk of renal overload gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion.
Fig.1 TRPM7 and the associated molecular pathways regulating tumor growth and spreading. (Federica, 2012)
This article reveals that the amount of uric acid excreted affects the function of transporters.
This article demonstrates that the solute carrier (SLC) transporters include GLUT9, MCT9, NPT4, NPT homolog (NPT5) and OAT10.
This article demonstrates that a missense variant of MCT9 (K258T) - rs2242206, can significantly increase the risk of renal overload gout. And the common missense variant rs2242206 is revealed to have an association with renal overload gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion.
This article demonstrates that MCT9 is expressed in the parathyroid, kidney, trachea, spleen and adrenal gland.
The authors use an in situ hybridization survey of all MCT subtypes and detect intense mRNA expressions of MCT1, MCT4, and MCT9 as well as GLUT1 in the placenta from gestational day 11.5.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC16A9 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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