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HighlightsSLC1A1, also known as excitatory amino acid transporter 3 (EAAT3), is a protein encoded by the SLC1A1 gene. Solute carrier family 1 member 1 is a member of high-affinity glutamate transporters that play a crucial role in the delivery of glutamate. In the brain, excitatory amino acid transporters are critical in terminating the postsynaptic effects of the neurotransmitter glutamate and maintaining extracellular glutamate levels below neurotoxicity levels. SLC1A1 also transports Aspartate, and mutation of SLC1A1 gene that is thought to cause dicarboxylic acidosis, also known as glutamine-aspartate transport defects. SLC1A1 protein is also the main pathway for neuronal absorption. Cysteine is a component of the major antioxidant glutathione, and mice lacking SLC1A1 show reduced glutathione levels in neurons, increased oxidative stress, and age-related neuronal loss, especially Melanin neurons.
| Basic Information of SLC1A1 | |
| Protein Name | Excitatory amino acid transporter 3 (EAAT3) |
| Gene Name | SLC1A1 |
| Aliases | Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P43005 |
| Transmembrane Times | 8 |
| Length (aa) | 524 |
| Sequence | MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF |
Excitatory amino acid transporter 3 (EAAT3), known as excitatory amino acid carrier 1 (EAAC1), represents a major neuronal member of the excitatory amino acid transport family, including EAATs 1-5. EAAT3 is mainly expressed in the hippocampus, followed by the cerebral cortex, striatum and thalamus. More specifically, the highest level of transcription of EAAT3 in mice is seen in the pyramidal layer of the hippocampus, CA1 to CA4, and the granule layer of the dentate gyrus, where it is widely distributed in all neurons. The EAAT3 protein has three major physiological functions: 1) uptake of synaptic glutamate, preventing glutamate from active synapses from spilling into the exogenous region; 2) providing glutamate as a precursor for gamma aminobutyric acid (GABA) synthesis; 3) Neuronal absorption of cysteine neurons, synthesis of intracellular glutathione (GSH) rate-limiting matrix in neurons.
Fig.1 The structure of SLC1A1 Protein.
These results suggest that partial loss of the mouse SLC1A1 gene results in haploinsufficiency associated with behavioral, histological, and biochemical changes that reflect an altered redox state and may promote behavioral characteristics and inflammation. The expression of the state is consistent with the observation of schizophrenia.
The new findings revealed that the Sequence Upstream of Exon 2 promotes transcription of 5′-Truncated SLC1A1.
These findings provide evidence that SLC1A1 affects basal ganglia-dependent repetitive behavior and suggests potential targets for drug development.
The authors found that miR-101b targets the neuronal glutamate transporter SLC1A1 by using a combination of in silico and in vitro analyses.
This article reveals that SLC1A1 has been upregulated 3-fold within 4 h of 1,25D-treatment, suggesting that SLC1A1 may be a direct target of the 1,25D-VDR complex.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC1A1 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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