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HighlightsThe Solute carrier family 1, member 4 is a protein which is encoded by the SLC1A4 gene in humans. It is also known as Alanine/serine/cysteine/threonine transporter 1 (ASCT-1). In melanocytes, SLC1A4 gene expression can be regulated by MITF. SLC1A4 can not only convert glutamate from neurons into synaptic nodes through the release of calcium ions, but also regulate the l-serine effluent through the absorption of glial cells and neurons. L-serine is used in the synthesis of various biomolecules, including NMDA glutamate receptors, D-serine and glycine.
| Basic Information of SLC1A4 | |
| Protein Name | Neutral amino acid transporter A |
| Gene Name | SLC1A4 |
| Aliases | Alanine/serine/cysteine/threonine transporter 1 (ASCT-1), SATT, Solute carrier family 1 member 4 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P43007 |
| Transmembrane Times | 9 |
| Length (aa) | 532 |
| Sequence | MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL |
Solute family 1A (SLC1A) includes excitatory amino acid transporters (EAATs), Alanine, serine, and cysteine transporters (ASCTs) and prokaryotic aspartate transporters GltPh. The transport of acidic amino acids is carried out by the co-transport of three Na+ ions and one proton, and the reverse transport of one K+ ion. In contrast, the amount of Na+ ions required is not well defined and the neutral amino acid exchange by ASCTs does not require the reverse transport of protons or K+ ions.
Fig.1 The structure of SLC1A4 Protein.
These results suggest that SLC1A4 (ASCT1) may represent an important pathway in the brain that relies on Na-serine flux, which regulates extracellular D-serine and NMDA receptor activity.
The conclusion is that at least one susceptible site for schizophrenia may be located in or near SLC6A5, while SLC1A4, SLC1A5, and SLC6A9 are unlikely to be the major susceptibility genes for schizophrenia in Japanese.
These results suggest that in many mutants that reduced substrate transport rates, there was no significant effect on the amplitude of the anion conduction activated by the sublayer compared to substrate exchange.
This article shows that ANKRD50 is involved in multiple parts of SNX27 – retromer –WASH complex machines in a direct and cooperative interaction network, which effectively recycles the SLC2A1 and SLC1A4, and potentially many other surface proteins.
Compared with the pre-competition season, the expression of the cellular receptors SLC1A4 and SLC1A5 was significantly reduced in the post-competitive muscle, but only the SLC1A4 protein was expressed throughout the muscle fibers.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC1A4 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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