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HighlightsSolute carrier family 22 member 10 (SLC22A10), also known as the organic anion transporter 5 (OAT5), is a protein encoded by the SLC22A10 gene. Organic anion transporter 5 (OAT5), is characterized by an organic anion/dicarboxylic acid exchanger. This protein is localized on the edge film of the proximal tubule straight segment (S3). Oatmeal 5 has been reported to interact with many anionic drugs such as bumetanide, furosemide, penicillin G, and non-steroidal anti-inflammatory drugs. Under pathological conditions, the function of organic anion exchangers in kidney cells has not been fully elucidated.
| Basic Information of SLC22A10 | |
| Protein Name | Solute carrier family 22 member 10 |
| Gene Name | SLC22A10 |
| Aliases | Organic anion transporter 5 (OAT5) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q63ZE4 |
| Transmembrane Times | 11 |
| Length (aa) | 541 |
| Sequence | MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEKA |
SLC22A10 is expressed only in the kidney, and its urinary excretion is considered to be an early biomarker of kidney damage. The organic anion transporter (OAT) family consists of a group of more than 10 transmembrane proteins belonging to the SLC22 (solute carrier 22) subfamily of the major promoter superfamily (MFS). The SLC22 subfamily also includes organic cation transporters (OCTs) and organic carnitine (zwitterion) transporter (OCTNs). OAT family members are very similar in the subclass of the SLC22 transmitter and have many structural features with other MFS proteins. Modeling, mutagenesis, and other studies are consistent with the notion that these transmembrane proteins are composed of approximately 540-560 amino acids, consisting of 12 transmembrane domains.
Fig.1 The structure of SLC22A10 Protein.
This article suggests that organic anions of different pathophysiological importance can be absorbed/eliminated by using the outward gradient of citric acid produced by NaDC1.
The results that imply urinary excretion of SLC22A10 can be considered as a potential non-invasive biomarker for kidney damage associated with vascular calcification.
This article reveals that in system physiology, the effects of various forms of SLC22A10 appear to be quite complex, and their effects are discussed in the context of remote sensing and signal transmission.
These results suggest that urinary excretion of SLC22A10 may be an early indicator of renal insufficiency, which is useful for detecting small changes in kidney structural and functional integrity.
This review introduced organic anion transporters and its regulatory mechanisms.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A10 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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