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HighlightsSolute carrier family 22 member 16 (SLC22A16), which is an organic anion/cation transporter, is a protein encoded by the SLC22A16 gene in humans. SLC22A16 is also known as Carnitine transporter 2(CT2), Fly-like putative transporter 2(FLIPT2; Flipt 2), Organic cation transporter OKB1 or Organic cation/carnitine transporter 6. It is highly similar to organic cation transporters in humans. The gene SLC22A16 is widely found in many mammals.
| Basic Information of SLC22A16 | |
| Protein Name | Solute carrier family 22 member 16 |
| Gene Name | SLC22A16 |
| Aliases | Carnitine transporter 2(CT2), Fly-like putative transporter 2(FLIPT2; Flipt 2), Organic cation transporter OKB1, Organic cation/carnitine transporter 6 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q86VW1 |
| Transmembrane Times | 12 |
| Length (aa) | 577 |
| Sequence | MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE |
The SLC22A16 (rs12210538 A/G) gene polymorphism is a non-synonymous polymorphism that replaces methionine with threonine at position 409. The expression of the SLC22A16 gene in cancer cells is associated with increased sensitivity to redox cytotoxicity. SLC22A16 is a high-affinity carnitine transporter. The absorption of SLC22A16 is partially dependent on sodium ions. SLC22A16 is thought to be a mechanism regulating the secretion of L-carnitine, from the epididymis of the testis into the lumen of sperm maturation. SLC22A16 also transports organic carbon such as tetraethylammonium (tea) and multi-crububicin. The intake of tea is inhibited by various organic foods. The absorption of doxorubicin is sodium-independent. SLC22A16 involves drug transport to FAC.
Fig.1 The structure of SLC22A16 Protein.
These results suggest that SLC22A16 may be a valuable prognostic marker in gastric cancer.
The results showed that at least one allele C of ABCB1 (rs10276036 C/T) polymorphic carrier and at least one allele A of SLC22A16 (rs12210538 A/G) polymorphism tend to be more susceptible to grade 3/4 febrile neutropenia.
The article reveals that in addition, iron consumption reduced the intake of 3H-spermidine, directly in line with the reduced level of polyamine importer SLC22A16.
These results indicate that patients who are more tolerant to FAC therapy and who are more likely to complete chemotherapy are at high doses without reducing dose, delay in treatment, and declining quality of life.
Clear orthological relationships of zebrafish slc22 and other vertebrate slc22 genes were established in this research. Because of their physiological and toxicological importance, slc22 members are highly conserved.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A16 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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