SLC26A7 Membrane Protein Introduction

Introduction of SLC26A7

SLC26A7 is encoded by the SLC26A7 gene and is also known as anion exchange transporter and solute carrier family 26 member 7. SLC26A7 is a member of the SLC26 transporter family, which has limited expression in different tissues to support critical physiological functions. It has been reported that SLC26A7 functions as a Cl⁻/HCO₃⁻ exchanger and/or as a Cl⁻ channel. SLC26A7 is abundantly expressed in the stomach and mediates Cl⁻/HCO₃⁻ exchange and the expression is limited to the basolateral membrane of gastric parietal cells.

Function of SLC26A7 Membrane Protein

SLC26A7 shows very restricted distribution, and it has been found only in gastric parietal cells and the intercalated cells of the outer medullary collecting duct. Unlike other members of the family that are expressed at the luminal membrane of epithelial cells, SLC26A7 was found at the basolateral membrane of both parietal cells and intercalated cells. It was reported that SLC26A7 functions as a coupled Formula exchanger and was thus suggested to play an important role in clearing formula from the parietal cells during acid secretion. Furthermore, SLC26A7 was reported to be markedly activated by cell shrinkage and thus mediate formula efflux into the hypertonic fluid of the collecting duct. Meanwhile, SLC26A7 is reported to be involved in cellular pH regulation in other epithelial cells leaves open the possibility that SLC26A7 is needed in Reissner’s membrane cells during perturbations of pH in either intracellular or extracellular pH.

Fig.1 Proposed structure of SLC26A7 membrane protein. (Chang, 2017)

Application of SLC26A7 Membrane Protein in Literature

1. Kim K.X., et al. Slc26a7 Chloride Channel Activity and Localization in Mouse Reissner’s Membrane Epithelium. PLoS ONE. 2014, 9(5): e97191. PubMed ID: 24810589
   
   

   This article reports that SLC26A7 participates in Cl⁻ transport in Reissner’s membrane epithelial cells. Meanwhile, SLC26A7 is also involved in cellular pH regulation in other epithelial cells leaves open the possibility that SLC26A7 is needed in Reissner’s membrane cells during local perturbations of pH.

2. Petrovic S., et al. SLC26A7: a basolateral Cl⁻/HCO₃⁻ exchanger specific to intercalated cells of the outer medullary collecting duct. American Journal of Physiology-Renal Physiology. 2004, 286(1): F161-F169. PubMed ID: 12965893
   
   

   This article proposes that SLC26A7 is a basolateral Cl⁻/HCO₃⁻ exchanger in intercalated cells of the outer medullary collecting duct and may play an important role in bicarbonate reabsorption in the medullary collecting duct.

3. Kim K.H., et al. SLC26A7 Is a Cl⁻ Channel Regulated by Intracellular pH. J. Biol. Chem. 2005, 280(8): 6463-6470. PubMed ID: 15591059
   
   

   This article suggests that the activity of SLC26A7 was inhibited by all inhibitors of anion transporters tested, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, diphenylamine-2-carboxylic acid, and glybenclamide. These findings reveal that SLC26A7 functions as a unique Cl⁻ channel that is regulated by intracellular H⁺.

4. Yin K., et al. Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice. Frontiers in Physiolog. 2017, 8: 307. PubMed ID: 28559854
   
   

   The data of this article indicate that SLC26A7 play an important role in ion transporters in the pH regulatory network during enamel maturation. The data obtained from double mutant animals (Slc26a1^−/− and Slc26a7^−/−) provide new evidence from a functional perspective to support the hypothesis that SLC26A1/SAT1 and SLC26A7/SUT1 are actively involved in ameloblast mediated pH regulation during maturation-stage amelogenesis.

5. Yin K., et al. SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS ONE. 2015, 10(12): e0144703. PubMed ID: 26671068
   
   

   This article shows that SLC26A1, SLC26A6, and SLC26A7 are novel participants in the extracellular transport of bicarbonate during enamel maturation and that their functional roles may be achieved by forming interaction units with Cftr.

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Reference

1. Chang Y-N & Geertsma Eric R. The novel class of seven transmembrane segment inverted repeat carriers. in Biol. Chem. 2017, p165.

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