Introduction of SLC29A1
Equilibrative nucleoside transporter 1 (ENT1) or SLC29A1 is a protein encoded by the SLC29A1 gene in humans. This gene has been found to have multiple alternative splice variants encoding the same protein. The protein is glycosylated after translation and expressed in all tissues except skeletal muscle. The highest levels are found in the liver, heart, testes, spleen, lungs, kidneys and brain.
|Basic Information of SLC29A1|
|Protein Name||Equilibrative nucleoside transporter 1|
|Aliases||ENT1, solute carrier family 29 member 1|
|Organism||Homo sapiens (Human)|
Function of SLC29A1 Membrane Protein
SLC29A1 gene is a member of the equilibrative nucleoside transporter family. It encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. SLC29A1 is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylmercaptopurine ribonucleoside (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.
Fig.1 Structure of SLC29A1 membrane protein.
Application of SLC29A1 Membrane Protein in Literature
This article suggests that the es transporter does not appear to be functionally variant in the human placenta, small intestine or erythrocytes.
This article reveals predicted topologies of ENT proteins are strikingly similar, suggesting evolutionary conservation of a prototypic structure.
This article suggests that hENT1 and hENT2 on the basolateral membrane function with concentrative nucleoside transporters on the apical membrane to mediate active reabsorption of nucleosides within the kidney.
Study of this protein should not only provide insights into the physiological roles of nucleoside transport but also open the way to improved therapies.
This article evaluates nucleoside transporter (SLC29A1) was identified as stomatin-interacting proteins. This finding is in line with the hypothesis that stomatin plays a role as membrane-bound scaffolding protein modulating transport proteins.
SLC29A1 Preparation Options
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