SLC2A10 Membrane Protein Introduction

Introduction of SLC2A10

Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10), also known as glucose transporter type 10 or GLUT-10, is a protein that in humans is encoded by the SLC2A10 gene. It is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis.

Basic Information of SLC2A10
Protein Name	Solute carrier family 2, facilitated glucose transporter member 10
Gene Name	SLC2A10
Aliases	Glucose transporter type 10, GLUT-10
Organism	Homo sapiens (Human)
UniProt ID	O95528
Transmembrane Times	12
Length (aa)	541
Sequence	MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS

Function of SLC2A10 Membrane Protein

The protein family of facilitative glucose transporters comprises 14 isoforms that share common structural features such as 12 transmembrane domains, N- and C-termini facing the cytoplasm of the cell, and an N-glycosylation side either within the first or fifth extracellular loop. SLC2A10, a member of the facilitative glucose transporter family, belongs to the class III subclass which is classified based on primary sequence comparisons. It has been reported that SLC2A10 is expressed in diverse human tissues, including heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney. Expression of SLC2A10 is also detected in human and mouse white adipose tissue as well as human and mouse adipocyte cell lines SGBS and 3T3L1, respectively. Studies have shown that deficiency for SLC2A10 in humans is associated with Arterial Tortuosity Syndrome, a rare autosomal recessive connective tissue disease that is characterized by widespread arterial involvement with elongation, tortuosity, and aneurysms of the arteries.

Fig.1 Two-dimensional models of class I + II and III GLUTs. (Barron, 2016)

Application SLC2A10 of Membrane Protein in Literature

Bento J.L., et al. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. BMC medical genetics. 2005, 6(1):42. PubMed ID: 16336637

This article indicates that sequence variants in or near GLUT10 are unlikely to contribute significantly to T2DM in Caucasian Americans.
Willaert A., et al. GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Human molecular genetics. 2011, 21(6):1248-59. PubMed ID: 22116938

This article aims to investigate whether SLC2A10/GLUT10 can serve as a link between TGFβ-related transcriptional regulation and metabolism during development. It suggests that glut10 is essential for cardiovascular development by facilitating both mitochondrial respiration and TGFβ signaling.
Chiarelli N., et al. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. International Journal of Developmental Biology. 2011, 55(2):229-36. PubMed ID: 21553381

This study finds that slc2a10 plays a key role during zebrafish development.
Jiang Y.D., et al. SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes. BMC medical genetics. 2010, 11(1):126. PubMed ID: 20735855

This article suggests that the genetic polymorphism of the SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes.
Faiyaz-Ul-Haque M., et al. A novel missense and a recurrent mutation in SLC2A10 gene of patients affected with arterial tortuosity syndrome. Atherosclerosis. 2009, 203(2):466-71. PubMed ID: 18774132

This article suggests that there exists an intro- and inter-familial phenotypic variability in arterial tortuosity patients carrying identical or different mutations in the SLC2A10 gene. While skin hyperextensibility, small joint hypermobility, and facial features are similarly expressed in these patients, there is a range of other phenotypes which include arterial tortuosity and associated complications, and abnormalities of other organs.

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Reference

Barron, et al. (2016). Facilitative glucose transporters: implications for cancer detection, prognosis, and treatment. Metabolism. 65(2): 124-139.

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