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HighlightsSolute carrier family 2, facilitated glucose transporter member 12 (SLC2A12), also known as glucose transporter type 12 or GLUT-12, is a protein that in humans is encoded by the SLC2A12 gene. It belongs to the class III hexose transporter family which is distinguished based on primary sequence comparisons.
| Basic Information of SLC2A12 | |
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 12 |
| Gene Name | SLC2A12 |
| Aliases | Glucose transporter type 12, GLUT-12 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q8TD20 |
| Transmembrane Times | 12 |
| Length (aa) | 617 |
| Sequence | MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET |
GLUT12 (SLC2A12) is a member of the class III hexose transporter family, which contains dileucine motifs- both at the N- and C-terminal end of the protein. The sequence of SLC2A12 presents all the characteristics of the GLUT family, in particular, the 12 putative trans-membrane domains required for function as a glucose transporter. It exhibits 40% amino acid homology with GLUT10 and 29% with GLUT4. The expression of SLC2A12 has been found in numerous tissues, including skeletal muscle, adipose tissue, small intestine, heart, placenta, and in the pregnant and lactating mammary gland, as well as in cancerous tissue of breast and prostate and widely expressed in the fetus. Studies have shown that SLC2A12 facilitates transport of glucose with an apparent preferential substrate affinity for glucose over the other hexoses studied, supporting the hypothesis that SLC2A12 acts to facilitate glucose transport in vivo in many different cells where it is expressed.
Fig.1 Schematic representation of the structure of the SLC2A glucose transporters. (Govers, 2014)
This article demonstrates that prostate cancer cells can increase the functional levels of GLUT12 through multiple mechanisms to promote glucose uptake and subsequent cell growth.
This study investigates glucose sensing and mediation, which are responsible for the high motility of MCF-7 cells. It suggests that GLUT12 plays a critical role in the model of breast cancer progression through high glucose concentrations.
The study aims to characterize the expression of the novel glucose transporter GLUT12 in the fetal membranes of the human placenta. Results show that GLUT12 is expressed in cells of human fetal membranes and suggest that GLUT12 may play a role in the facilitation of glucose transport into these cells.
The goal of this study is to characterize the functional properties of GLUT12 by radiotracer and electrophysiological methods. Data obtained from the results indicate that GLUT12 may have a specific physiological role in glucose homeostasis, which needs to be discovered.
This article aims to investigate the expression of GLUT12 in frontal cortex from Alzheimer's disease patients. Results suggest that the expression level of GLUT12 is significantly higher in the AD when compared to aged controls.
To provide high-quality membrane protein products, we have developed an advanced Magic™ membrane protein production platform which enables many options, from which we will find you the perfect one. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A12 antibody development services.
Aided by years of experience and professional scientists, Creative Biolabs is confident in promoting global customers’ programs. In addition to SLC2A12 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.
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