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HighlightsProton myo-inositol cotransporter (H(+)-myo-inositol cotransporter, Hmit), also known as H(+)-myo-inositol symporter or solute carrier family 2 member 13 (SLC2A13), is a protein that in humans is encoded by the SLC2A13 gene. It belongs to the class III GLUT family.
| Basic Information of SLC2A13 | |
| Protein Name | Proton myo-inositol cotransporter |
| Gene Name | SLC2A13 |
| Aliases | H(+)-myo-inositol cotransporter, Hmit, H(+)-myo-inositol symporter, solute carrier family 2 member 13 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q96QE2 |
| Transmembrane Times | 12 |
| Length (aa) | 648 |
| Sequence | MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSPRITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDVE |
HMIT (SLC2A13) is a member of the class III GLUT family which is restricted to an intracellular location. It is a glycosylated protein containing three conserved internalization signals: an endoplasmic reticulum (ER) retention signal in the N-terminal region, a dileucine internalization signal and a tyrosine-based internalization motif at the C-terminal. Despite low expression level in adipose tissue and kidney, HMIT is predominantly expressed in the brain, with high expression found in hippocampus, hypothalamus, cerebellum, and brainstem. Surprisingly, no sugar transport activity has been found for HMIT. Instead, HMIT has been identified as an H1-coupled myoinositol symporter with a Km of about 100 lM. More recently, HMIT has been shown to transport inositol-3-phosphate (IP3). Furthermore, studies have shown that HMIT is inhibited by the common GLUT inhibitors phloretin, phlorizin, and cytochalasin B, although at high concentrations.
Fig.1 Protein model for human SMIT1 and postulated splice variants. (Schneider, 2015)
This article aims to find new CSC markers for oral squamous cell carcinoma (OSCC). It suggests that SLC2A13 can be a potential marker for CSC in various tumors.
This article investigates the functional characterization of a novel H(+)-myo-inositol co-transporter, HMIT, expressed predominantly in the brain. It indicates that HMIT has a key role in the control of myo-inositol brain metabolism.
This article is conducted to study the expression and function of the recently identified H+/myo-inositol transporter (HMIT) in PIns signaling. It suggests that HMIT can transport inositol triphosphate, indicating unanticipated intracellular functions for this transporter that may be relevant to mood control.
This article investigates the protein localization of HMIT and Na+/myo-inositol cotransporter 1 (SMIT1) in the stria vascularis by immunohistochemistry. It suggests that HMIT is expressed in marginal cells and basal cells of the stria vascularis, indicating that HMIT may play important roles in the homeostasis of cochlear fluids, for example by participating in pH regulation and osmoregulation.
To provide high-quality membrane protein products, we have developed an advanced Magic™ membrane protein production platform which enables many options, from which we will find you the perfect one. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A13 antibody development services.
Creative Biolabs is confident in promoting global customers’ programs. In addition to SLC2A13 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.
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