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HighlightsSolute carrier family 2, facilitated glucose transporter member 2 (SLC2A2), also known as Glucose transporter type 2, liver (GLUT-2), is a protein that in humans is encoded by the SLC2A2 gene. It is the principal transporter for transfer of glucose between liver and blood that enables protein facilitated glucose movement across cell membranes. In addition to transfer glucose, it is also capable of transporting fructose.
| Basic Information of SLC2A2 | |
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 2 |
| Gene Name | SLC2A2 |
| Aliases | Glucose transporter type 2, GLUT-2 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P11168 |
| Transmembrane Times | 12 |
| Length (aa) | 524 |
| Sequence | MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV |
GLUT2 (SLC2A2), a member of the GLUTs family, is a low-affinity, high capacity transporter. It has been reported that SLC2A2 mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells. In addition to transport glucose, it also transports galactose, D-mannose, and D-fructose. Recently, SLC2A2 was shown to transport glucosamine with high affinity. What’s more, SLC2A2 may also participate in the release of absorbed or reabsorbed glucose into the bloodstream at the basolateral membrane of the respective epithelial cells in the small intestine and kidney. In the past years, the consequences of SLC2A2 deficiency have been analyzed in detail for the various tissues, where SLC2A2 is involved and/or essential in maintaining whole-body glucose homeostasis.
Fig.1 Functional β-cells respond to increase glucose levels by increasing insulin secretion. (Pagliuca, 2013)
This article finds that the glucose transporter GLUT2 is highly expressed in the lumen of sweat glands from atopic dermatitis (AD) patients. AD patients with chronic inflammation have significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. It indicates that the increased glucose levels might be affected by AD severity and phenotype.
This article demonstrates for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppress GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells.
This report finds that SLC2A2 is associated with clinical stages and independently associated with overall survival in patients with hepatocellular carcinoma (HCC). It indicates that SLC2A2 may be used as a new prognostic factor for HCC.
This article suggests that p-CA modulates glucose and lipid metabolism via GLUT 2 activation in the pancreatic and has potentially beneficial effects in improving or treating metabolic disorders.
This report suggests that RGZ could stimulate the release and synthesis of insulin through the upregulation of GLUT-2, GCK, and BETA2/NeuroD gene expression.
To provide multiple membrane protein products, we have developed an advanced Magic™ membrane protein production platform which enables many options, from which we will find you the perfect one. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A2 antibody development services.
Creative Biolabs is dedicated to promoting global customers’ programs. In addition to SLC2A2 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.
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