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SLC39A10 Membrane Protein Introduction

Introduction of SLC39A10

Zinc transporter ZIP10 also known as solute carrier family 39 member 10 (SLC39A10) is a protein that in humans is encoded by the SLC39A10 gene. This transporter is mainly located on the plasma membrane and may act as a zinc-influx transporter. It is reported to be expressed in the brain, erythroid cells, and kidney. The gene coding this protein is located on chromosome 2q33.1. Structurally, this protein has multiple transmembrane segments. Moreover, it belongs to the LIV-1 subfamily that shares a highly conserved putative metalloprotease motif (HEXPHEXGD) in addition to the histidine-rich loop domain.

Basic Information of SLC39A10
Protein Name Zinc transporter ZIP10
Gene Name SLC39A10
Aliases Solute carrier family 39 member 10, Zrt- and Irt-like protein 10, ZIP10
Organism Homo sapiens (Human)
UniProt ID Q9ULF5
Transmembrane Times 7
Length (aa) 831
Sequence MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF

Functions of SLC39A10 Membrane Protein

Altered expression of SLC39A10 has been observed in cancers and these changes may play causal roles in cancer progression. Firstly, SLC39A10 has been reported to mediate the migration and invasive behaviors of breast cancer cells. Secondly, SLC39A10 mRNA expression is proposed as a possible biomarker for the aggressive behavior of renal cell carcinoma and a promising target of novel treatment strategies. Moreover, SLC39A10 plays critical roles in epidermal development, ablating SLC39A10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Besides, SLC39A10 is one of the SLC39A transporters that participate in immune regulation by regulating intracellular Zn levels. Additionally, SLC39A10 can form a heteromer with ZIP6 and thus regulates embryonic development and cell migration.

Zinc transporter SLC39A10 facilitates antiapoptotic signaling during early B-cell development. Fig.1 Zinc transporter SLC39A10 facilitates antiapoptotic signaling during early B-cell development. (Miyai,2014)

Application of SLC39A10 Membrane Protein in Literature

  1. Bin B.H., et al. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Proceedings of the National Academy of Sciences. 2017: 201710726. PubMed ID: 29078349

    This study investigated the role of zinc transporter ZIP10 in epidermal development. The results indicated that ZIP10 played critical roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis.

  2. Gao H., et al. Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proceedings of the National Academy of Sciences. 2017, 114(49): 12940-12945. PubMed ID: 29180421

    Using macrophage-specific Slc39a10-knockout mice, this study demonstrated that Slc39a10 played an essential role in promoting macrophage survival through a Zn/p53-dependent axis in response to inflammatory stimuli.

  3. Miyai T., et al. Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proceedings of the National Academy of Sciences. 2014, 111(32): 11780-11785. PubMed ID: 25074913

    This study investigated ZIP10, a Zn transporter expressed in the early B-cell developmental process. The findings indicated that ZIP10 facilitated anti-apoptotic signaling during early B-cell development.

  4. Foster M., et al. Zinc transporter gene expression and glycemic control in post-menopausal women with type 2 diabetes mellitus. Journal of Trace Elements in Medicine and Biology. 2014, 28(4): 448-452. PubMed ID: 25156968

    In postmenopausal women with Type 2 DM, this article investigated the effects of supplementation with zinc and flaxseed oil on the gene expression of different zinc transporters and metallothionein, and marker s of glycemic control.

  5. Hojyo S., et al. Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proceedings of the National Academy of Sciences. 2014, 111(32): 11786-11791. PubMed ID: 25074919

    Using mice with a conditional knockout ZIP10 in mature B cells, this article demonstrated that ZIP10 controlled the B-cell receptor signal strength as a positive regulator of CD45R, thereby setting a threshold for B-cell signaling.

SLC39A10 Preparation Options

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Reference

  1. Miyai T, et al. (2014). Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proceedings of the National Academy of Sciences. 111(32): 11780-11785.

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