Solute carrier family 41 member 2 (SLC41A2) is a transmembrane protein that in human is encoded by SLC41A2 gene. SLC41A2 belongs to the solute carrier family 41 (SLC41), which is linked to Mg2+ transport in human cells. Like the other two family member (SLC41A1 and A3), SLC41A2 protein has distant homology to the prokaryotic Mg2+ transfer protein termed as MgtE. SLC41A2 protein is widely expressed in normal human tissues, including lymph nodes, lungs, stomach, testis, and skin with the highest expression level, followed by heart, intestine, spleen, kidneys and breast showing moderate expression.
|Basic Information of SLC41A2|
|Protein Name||Solute carrier family 41 member 2|
|Organism||Homo sapiens (Human)|
Intracellular magnesium, especially the ionized fraction (Mg2+), is one of the most major intracellular divalent cations and is required for the regulation of a wide variety of cellular functions. Previous data from numerous studies have illustrated that Mg2+ transporters played crucial roles in pathways that are involved in cell signaling, metabolism, growth, and proliferation. The SLC41 family of vertebrate magnesium transporters is identified as a unique family among the SLC superfamily, which comprises 44 families of proteins involved in the transport of numerous inorganic and organic solutes. According to a study that expressed SLC41A2 in Xenopus oocytes, SLC41A2 is proved to be an Mg2+ channel that might be involved in cellular magnesium homeostasis. Although there is only very limited knowledge on the molecular biology, physiology and exact functions of SLC41A2, this protein indeed acts as a plasma membrane Mg2+ transporter. Currently, no link has been established between SLC41A2 protein and any known diseases.
Fig.1 Mg2+ transporters in vertebrate cells. (Sahni, 2013)
This study aims to explore the transcriptomics, cellular localization, topology, function, and related human diseases of the three numbers of the SLC41 family.
Authors of this article focus on the SLC41 family of magnesium transporters, including SLC41A1-A3.
The results of this study suggest that SLC41A2 protein functions as a plasma-membrane Mg2+ transporter in vertebrate cells.
This article demonstrates that SLC41A2 acts as a plasma-membrane Mg2+ transporter in vertebrate cells.
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