Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier family 41 member 3 (SLC41A3) is a transmembrane protein that in human is encoded by SLC41A3 gene. Solute carrier family 41 member 3 belongs to the solute carrier family 41 (SLC41). SLC41 family consists of three members A1, A2, and A3. Like SLC41A1 and A2, the SLC41A3 protein comprises two “MgtE-like domains” displaying homology to the prokaryotic Mg2+ transporter, termed as the MgtE. For SLC41A3 protein, it is broadly expressed in liver, duodenum, colon, small intestine, stomach, urinary bladder, brain and etc.
| Basic Information of SLC41A3 | |
| Protein Name | Solute carrier family 41 member 3 |
| Gene Name | SLC41A3 |
| Aliases | N/A |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q96GZ6 |
| Transmembrane Times | 10 |
| Length (aa) | 507 |
| Sequence | MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI |
Currently, there is only very limited knowledge on the molecular biology and exact functions of SLC41A3. However, SLC41A3 protein has been identified as the first mammalian mitochondrial Mg2+ efflux system. And this efflux mechanism is temperature sensitive and Na+-dependent. Flexible, yet tightly regulated, intracellular Mg2+ homeostasis (IMH) is required for the significant role of Mg2+ (magnesium) in normal cellular physiology. Clinical studies have suggested that administration of magnesium can ensure cardioprotective benefits during acute myocardial infarction (MI) as well as suppression of cardiac arrhythmias. It has been demonstrated that the addition of magnesium during and prior to cardiac injury such as ischemia-reperfusion may significantly diminish ischemic damage. Some researches have shown that SLC41A1-A3 family has been identified as one of the key magnesium/sodium exchange channels. Further, voltage-gated K+ channel beta 2 (Kvβ2) subunit is proved to be a novel regulator to SLC41A3 and plays an essential role in SLC41A3 expression as well as function within the heart.
Fig.1 Computer predicted-model (TMPred) of SLC41A3 topology. (Fleig, 2013)
This article summarized the effects of Mg2+ on mitochondrial functions and showed that mitochondrial extruder SLC41A3 was involved in the regulation of the whole-body Mg2+ balance.
This study found that SLC41A3 was a new factor for Mg(2+) handling.
Authors of this article identified SLC41A3 as the first mammalian mitochondrial Mg(2+) efflux system, which significantly enhanced the understanding of intracellular Mg(2+) homeostasis.
This study attempted to investigate the transcriptomics, cellular localization, topology, function, and related human diseases of the three numbers of the SLC41 family.
Our Magic™ membrane protein production platform enables robust reconstitution forms as well as multiple active formats for membrane proteins. To prepare the soluble and functional target protein of your interest, we are willing to provide customized services with fast turnaround times. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC41A3 antibody development services.
Creative Biolabs has extensive experience in membrane protein preparation and is able to combine the most advanced technology around the world. Our scientists aim to accelerate access to a comprehensive solution for membrane protein studies for our worldwide clients. Please feel free to contact us for more details.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
