Introduction of SLC44A5
SLC44A5, also known as CTL5, is an integral membrane protein which belongs to the CTL (choline transporter-like) family. It is encoded by SLC44A5 gene and has 3 isoforms produced by alternative splicing. The longest isoform has 710 acid amino acid residues with 10 transmembrane helices, 6 cytoplasmic domains, and 5 extracellular domains. SLC44A5 is highly expressed in skin, testis, brain, colon, and esophagus.
|Basic Information of SLC44A5|
|Protein Name||Choline transporter-like protein 5|
|Organism||Homo sapiens (Human)|
Function of SLC44A5 Membrane Protein
SLC44A5 is a choline transporter which is involved in the membrane-spanning transport of choline. Although the functional research of SLC44A5 is relatively less, a study has shown that SLC44A5 is associated with hepatocellular carcinoma (HCC) carcinogenesis and progression. The higher expression levels of SLC44A5 are detected in the HCC tissues compared with the normal tissues. And SLC44A5 knockdown may downregulate the expression of cell cycle markers, cyclin-dependent kinase 2, and pro-proliferating cell nuclear antigen thereby suppressing cell viability and arresting the cells in the G1 phase of the cell cycle. Besides, SLC44A5 knockdown also reduces the expression levels of apoptosis markers, caspase-9 and caspase-3, resulting in cell apoptosis and invasion inhibition. Hence SLC44A5 can be regarded as a potential therapeutic target for HCC. In addition, cell viability assays suggest a role of SLC44A5 in the regulation of cell proliferation. And SLC44A5 knockdown promotes cell proliferation resulting in the larger body of calves which may lead to the rate of dystocia.
Fig.1 Biochemical network of ethanolamine and choline phospholipid metabolism showing crosstalk between these two metabolic cycles. (Cheng, 2016)
Application of SLC44A5 Membrane Protein in Literature
The article demonstrates that SLC44A5 play a role in the hepatocellular carcinoma carcinogenesis and progression, indicating that SLC44A5 may be a potential therapeutic target for cancer.
The investigation suggests that reduced SLC44A5 expression may result in higher birth weights in calves via promoting cell proliferation.
The study identifies eight neuronal genes (NEGR1, SLC44A5, PDE4B, LPHN2, ELTD1, ST6GALNAC3, ST6GALNAC5, and TTLL7) that are associated with subcutaneous fat thickness.
The study shows that SLC44A5 gene in donors is significantly associated with overall survival (OS) after HLA-matched unrelated donor blood and marrow transplantation.
SLC44A5 Preparation Options
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