Solute carrier family 9A4 (SLC9A4) is also known as sodium-hydrogen antiporter 4 (NHE-4) or sodium/hydrogen exchanger 4. It is encoded by the SLC9A4 gene in humans. SLC9A4 is biased expressed in stomach and kidney. The SLC9A4 gene is conserved in Rhesus monkey, chimpanzee, dog, mouse, rat, cow, chicken, and frog. It belongs to the solute carrier family 9, and functions as a Na+/H+ antiporter. SLC9A4 is involved in pH homeostasis, and signal transduction.
|Basic Information of SLC9A4|
|Protein Name||Sodium/hydrogen exchanger 4|
|Aliases||Na(+)/H(+) exchanger 4, NHE-4, Solute carrier family 9 member 4, NHE4|
|Organism||Homo sapiens (Human)|
As a member of sodium-hydrogen exchanger (NHE) protein family, SLC9A4 mediates the sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and plays an important role in cell pH regulation and cell volume. As a member of SLC9A family, SLC9A4 might be affected by clinical exposure to NSAIDs just like other family members and this will lead to transport modulation and barrier function. SLC9A4 is one of the major proton extruding system driven by a sodium ion gradient. It plays a critical role in signal transduction and plays a specialized role in rectifying cell volume in the kidney upon response to fluctuations of hyperosmolar-stimulated cell shrinkage. SLC9A4 is insensitive to ethylisopropylamiloride and amiloride. In addition, SLC9A4 can be activated by cell shrinkage in a sustained intracellular acidification dependent approach. It can also affect the potassium and proton exchange and sodium/proton exchange. SLC9A4 is also related to pediatric celiac disease.
Fig.1 Topology of SLC9A family. (Hendus-Altenburger, 2014)
This article indicates that SLC9A4 is identified as a genomic variant in pediatric celiac disease by a next-generation sequencing approach.
This article shows that the enhanced expression levels of NHE1, 2 and 4 in the cervix can help to restore pH modulating, and this can prevent cervicovaginal complications related to menopause.
This article indicates that SLC9A4 is up-regulated in the male hippocampus compared with other samples.
This article shows the different expression levels of sodium/hydrogen exchanger (NHE1, 2, 4) under different sex steroid treatment and at different estrous cycle phases.
This article demonstrates that SLC9A4 plays a critical role in keeping cellular pH homeostasis over a wide range of pH spectrum.
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