Solute carrier family 9A5 (SLC9A5) is also known as sodium-hydrogen antiporter 5 (NHE-5) or sodium/hydrogen exchanger 5. SLC9A5 is encoded by the SLC9A5 gene in humans. It’s biased expressed in spleen, testis and 7 other tissues. The SLC9A5 gene is conserved in Rhesus monkey, dog, chimpanzee, cow, chicken, mouse, rat, zebrafish, mosquito, fruit fly, and frog. It belongs to the solute carrier family 9, and functions as a Na+/H+ antiporter. SLC9A5 is involved in cellular pH homeostasis, and signal transduction.
|Basic Information of SLC9A5|
|Protein Name||Sodium/hydrogen exchanger 5|
|Aliases||Na(+)/H(+) exchanger 5, Solute carrier family 9 member 5, NHE5|
|Organism||Homo sapiens (Human)|
SLC9A5 mediates the sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and plays an important role in cell pH regulation and cell volume. As a member of SLC9A family, SLC9A5 expression might be affected by clinical exposure to NSAIDs and this may lead to transport modulation and barrier function. SLC9A5 has a regulatory role in neuronal signaling through proton movement and in synaptic transmission. In addition, SLC9A5 is functionally associated with endosomal acidification, modulating TrkA cell-surface targeting, NGF-induced neurotrophin signaling and possibly neuronal differentiation. SLC9A5 can interact with AMPK to modulate the pH homeostasis of hippocampal neurons. Moreover, NHE5 deficiency impairs cell migration and leads to loss of cell polarity. Furthermore, SLC9A5 plays a functional role in regulating learning and memory in mice, and this implies that SLC9A5 can be a potential therapeutic target for improving cognition.
Fig.1 Model of endosomal and synaptic functions of NHE5. (Diering, 2014)
This article indicates that SLC9A5 plays a functional role in regulating learning and memory in mice, and this implies that SLC9A5 can be a potential therapeutic target for improving cognition.
This article shows that NHE5 deficiency impairs cell migration and leads to loss of cell polarity.
This article indicates that SLC9A5 can interact with AMPK to modulate the pH homeostasis of hippocampal neurons.
This article shows that NHE5 has a regulatory role in neuronal signaling through proton movement and in synaptic transmission.
This article demonstrates that SLC9A5 is functionally associated with endosomal acidification, modulating TrkA cell-surface targeting, NGF-induced neurotrophin signaling and possibly neuronal differentiation.
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