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SLCO1B3 Membrane Protein Introduction

Introduction of SLCO1B3

SLCO1B3, solute carrier organic anion transporter family member 1B3, is also known as solute carrier family 21 member 8 (SLC21A8). It is encoded by human SLCO1B3 gene and belongs to the SLC21A family of solute carriers. This gene is conserved in dog, Rhesus monkey, mouse, rat, and cow. It is documented that 55 organisms have orthologs with this gene. It’s restrictedly expressed in the liver and is involved in sodium-independent uptake of organic anions.

Basic Information of SLCO1B3
Protein Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Aliases LST2, OATP1B3, OATP8, SLC21A8
Organism Homo sapiens (Human)
UniProt ID Q9NPD5
Transmembrane Times 12
Length (aa) 695
Sequence MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN

Function of SLCO1B3 Membrane Protein

SLCO1B3 is a sodium-independent transmembrane transporter, which is involved in the sodium-independent uptake of numerous endogenous compounds, such as leukotriene C4, 17-beta-glucuronosyl estradiol and bilirubin. In addition, SLCO1B3 is also involved in the clearance of organic anions and bile acids from the liver. Also, it has been reported that SLCO1B3 polymorphisms are critical for optimizing the agent dose of voriconazole. Especially, cancer type SLCO1B3 mRNA can be potential serum-based colorectal cancer (CRC) biomarker. In addition, SLCO1B3 can be regarded as a biomarker for warfarin dose adjustment in Chinese populations. Moreover, SLCO1B3 activity can be inhibited by bortezomib in a substrate-dependent manner. In the clinic, SLCO1B3 has been found to be associated with prostate cancer progression and testicular cancer.

Model of the transmembrane pore of OATP1B1 and OATP1B3. Fig.1 Model of the transmembrane pore of OATP1B1 and OATP1B3. (Gruetz, 2016)

Application of SLCO1B3 Membrane Protein in Literature

  1. Allegra S., et al. Pharmacogenetic of voriconazole antifungal agent in pediatric patients. Pharmacogenomics. 2018, 19(11): 913-925. PubMed ID: 29914286

    This article indicates that the SLCO1B3 polymorphisms are critical for optimizing the agent dose of voriconazole.

  2. Morio H., et al. Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker. Biol Pharm Bull. 2018, 41(3): 445-449. PubMed ID: 29491222

    This article demonstrates that cancer type SLCO1B3 mRNA can be as a potential serum-based CRC biomarker.

  3. Malagnino V., et al. LST-3TM12 is a member of the OATP1B family and a functional transporter. Biochem Pharmacol. 2018, 148: 75-87. PubMed ID: 29248594

    This article indicates that LST-3TM12 is a functional splice variant transporter of SLCO1B3 in the ER of human liver.

  4. Cai L.L., et al. Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population. Sci Rep. 2017, 7(1): 17379. PubMed ID: 29234073

    This article shows that SLCO1B3 can be as a biomarker for warfarin dose adjustment in Chinese populations.

  5. Alam K., et al. Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner. PLoS One. 2017, 12(11): e0186924. PubMed ID: 29107984

    This article shows that SLCO1B3 activity can be inhibited by bortezomib in a substrate-dependent manner.

SLCO1B3 Preparation Options

To facilitate the membrane protein preparation services for basic research, we have developed a series of Magic™ membrane protein production platform to meet different requirements. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLCO1B3 antibody development services.


Creative Biolabs is committed to providing high-quality products and membrane protein services to promote customers’ projects. We are dedicated to easing the basic research and any customized consultant is welcomed. For more detailed information, please feel free to contact us.

Reference

  1. Gruetz M, et al. (2016). Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1). Biochim Biophys Acta. 1858(11): 2894-2902.

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