SLCO2A1 Membrane Protein Introduction

Introduction of SLCO2A1

SLCO2A1, the official full name is solute carrier organic anion transporter family member 2A1, which owns 12 transmembrane domains. It is encoded by the SLCO2A1 gene in humans and belongs to SLC21A family of solute carriers. This gene is conserved in chimpanzee, cow, chicken, rat, dog, mouse, Rhesus monkey, and frog. 227 organisms have orthologs with this gene. SLCO2A1 is broadly expressed in lung, thyroid, and 20 other tissues, and is involved in uptake and clearance of prostaglandins in different tissues.

Basic Information of SLCO2A1
Protein Name	Solute carrier organic anion transporter family member 2A1
Gene Name	SLCO2A1
Aliases	OATP2A1, SLC21A2
Organism	Homo sapiens (Human)
UniProt ID	Q92959
Transmembrane Times	12
Length (aa)	643
Sequence	MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI

Function of SLCO2A1 Membrane Protein

SLCO2A1 is also known as solute carrier family 21 member 2 (SLC21A2), which belongs to the 12-membrane-spanning superfamily of solute carriers. As a member of the prostaglandin transporter and organic anion transporter family, SLCO2A1 mediates uptake and clearance of prostaglandins in different tissues. Also, SLCO2A1 is a necessary core component of the Maxi-Cl channel which is the most efficient pathway to regulate the fluxes of inorganic and organic anions including ATP. In addition, SLCO2A1 is highly associated with colon cancer progression through PGE2 uptake into the endothelial cells. Moreover, it plays a functional role in the metabolic clearance of prostaglandins. These reported functions are located at cytoplasmic vesicle or organelle membranes. It’s associated with various physiological and pathophysiological processes in diverse organs. Furthermore, mutations in SLCO2A1 are associated with primary hypertrophic osteoarthropathy, and SLCO2A1 is necessary for body temperature modulation during fever.

Fig.1 Crystal structure of wild-type SLCO2A1. (Cheng, 2013)

Application of SLCO2A1 Membrane Protein in Literature

Sabirov R.Z., et al. The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel. EMBO J. 2017, 36(22): 3309-3324. PubMed ID: 29046334

This article indicates that the SLCO2A1 is a necessary core component of the Maxi-Cl channel.
Nakanishi T., et al. A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer. Sci Rep. 2017, 7(1): 16567. PubMed ID: 29185482

This article demonstrates that SLCO2A1 can promote tumor progression through PGE2 uptake into the endothelial cells, and SLCO2A1 inhibition can improve colon cancer outcomes.
Nakanishi T. and Tamai I. Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins. AAPS J. 2017, 20(1): 13. PubMed ID: 29204966

This article shows the physiological and pathological importance mediated by SLCO2A1.
Sun F., et al. Primary Hypertrophic Osteoarthropathy With SLCO2A1 Mutation in a Chinese Patient Successfully Treated With Etoricoxib. J Clin Rheumatol. 2018, 24(3): 164-167. PubMed ID: 29239930

This article shows that the primary hypertrophic osteoarthropathy with mutated SLCO2A1 can be treated with Etoricoxib in a Chinese patient.
Villarreal-Martínez A., et al. Primary hypertrophic osteoarthropathy: Report of two novel genetic variants in the SLCO2A1 gene in two Mexican patients. Indian J Dermatol Venereol Leprol. 2018, 84(4): 446-447. PubMed ID: 29770782

This article shows the new genetic variants of SLCO2A1 in Mexican patients with primary hypertrophic osteoarthropathy.

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Reference

Cheng R, et al. (2013). Three novel mutations in the SLCO2A1 gene in two Chinese families with primary hypertrophic osteoarthropathy. Eur J Dermatol. 23(5): 636-9.

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