SLCO3A1, the official full name is solute carrier organic anion transporter family member 3A1 which owns 12 transmembrane domains. It is encoded by the SLCO3A1 gene in humans and belongs to the organic anion-transporting polypeptide family of membrane proteins. This gene is conserved in chimpanzee, cow, mouse, dog, rat, zebrafish, Rhesus monkey, chicken, and frog. 207 organisms have orthologs with this gene. SLCO3A1 is broadly expressed in lung, testis, and 23 other tissues, and is involved in sodium-independent transport of organic anions.
|Basic Information of SLCO3A1|
|Protein Name||Solute carrier organic anion transporter family member 3A1|
|Aliases||OATP3A1, OATPD, SLC21A11|
|Organism||Homo sapiens (Human)|
SLCO3A1 is also known as SLC21A11 which belongs to the 12-membrane-spanning superfamily of solute carriers. SLCO3A1 mediates uptake of sodium-independent transport of organic anions, such as estrone-3-sulfate. SLCO3A1 also is involved in the transport of prostaglandins (PG) E1 and E2, deltorphin II, thyroxine (T4), vasopressin and BQ-123, while it’s not involved in the transport of DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), taurocholate, estrone-3-sulfate, DHEAS or digoxin. In addition, SLCO3A1 can transport bile acid efflux which can be upregulated as an adaptive response to cholestasis. SLCO3A1 is involved in drug-drug interactions through increasing uptake of simvastatin acid, and this could influence clinical outcomes. Moreover, SLCO3A1 is associated with Crohn’s disease via regulating NF-kB activity and intestinal perforation. Also, SLCO3A1 is associated with nicotine dependence through meta-analysis, and it’s also involved in the uptake of hormones during breast cancer development.
Fig.1 rs207959 T/C elevates SLCO3A1 mRNA and protein expression levels in colon and small intestine tissue of normal, non-CD diseases, and CD patients. (Wei, 2014)
This article demonstrates that SLCO3A1 can transport bile acid efflux which can be upregulated as an adaptive response to cholestasis.
This article indicates that SLCO3A1 is involved in drug-drug interactions by increasing uptake of simvastatin acid, and this could influence clinical outcomes.
This article shows the DNA methylation involved in OATP3A1 downregulation in colorectal carcinogenesis.
This article shows that SLCO3A1 is associated with Crohn's disease by regulating NF-kB activity and intestinal perforation.
This article shows that SLCO3A1 is associated with nicotine dependence through meta-analysis, and this study provides potential insights into the pathogenesis of ND.
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