The solute carrier organic anion transporter family member 4A1 (SLCO4A1), also known as OATP4A1, is a multiple transmembrane protein encoded by the SLCO4A1 gene. SLCO4A1 is one of the organic anion-transporting polypeptides (referred to as ‘OATPs’ in humans and as ‘Oatps’ in other species) which belong to the solute carrier class (SLC) superfamily as members of the solute carrier organic anion transporter family (SLCO). They are widely expressed in many human tissues and are responsible for the Na+-independent uptake of large amphiphilic organic anions to cells. They transport a variety of endogenous and xenobiotics, including hormones and their combinations, as well as a variety of drugs, such as several anticancer drugs.
|Basic Information of SLCO4A1|
|Protein Name||Solute carrier organic anion transporter family member 4A1|
|Aliases||Colon organic anion transporter, Organic anion transporter polypeptide-related protein 1, Organic anion-transporting polypeptide E, Sodium-independent organic anion transporter E, Solute carrier family 21 member 12|
|Organism||Homo sapiens (Human)|
Transport proteins are essential for the absorption, distribution, and excretion of drugs and other endogenous and xenobiotics that cannot be freely transported through the cell membrane. SLCO4A1 is a multispecific transporter that can transport a variety of structurally unrelated compounds. SLCO4A1 is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogens. The expression of SLCO may or may not be tissue-specific and SLCO is expressed throughout the body. In normal tissues, SLCO4A1 is widely expressed, with the highest levels of mRNA expression in the heart and placenta, followed by lung, liver, skeletal muscle, kidney and pancreas. In addition, SLCO4A1 is highly expressed in several cancers, such as colorectal cancer. It plays an important role in colorectal cancer cell proliferation and carcinogenesis. SLCO4A1 expression may be an effective prognostic marker, indicative of tumor growth and metastasis.
Fig.1 SLC drug transporter membrane topology. The blue cylinder represents the predicted transmembrane structure. Yellow, green or red circles represent N-glycosylation and phosphorylation sites and important cysteine residues, respectively. (Walsh, 2015)
This article shows that SLCO4A1 may be an important marker of poor prognosis in colorectal cancer and plays an important role in the proliferation, migration, invasion, and carcinogenesis of colorectal cancer cells.
This study identifies the expression pattern of 28 human SLC transporters in human skin, with most SLC transporter family members being highly or moderately expressed in the liver and confined to the skin and small intestine.
This study confirms and evaluates the expression of six different SLC transporters in different cultured RPMI 2650 cells as well as human nasal mucosa specimens.
This review reports that organic anion transporter may function in long-distance inter-tissue communication by regulating levels of signaling molecules and key metabolites in tissues and body fluids.
This study reveals for the first time the interaction between icariin and a series of basic SLCs and the results suggest that icariin may compete with specific SLC drugs, which may affect the efficacy of icariin treatment.
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