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Small Conductance Calcium-activated Potassium Channel Protein Family

Small conductance calcium-activated potassium channel protein (protein SK) family forms a voltage-independent potassium channel which is activated by intracellular calcium. And the activation is followed by membrane hyperpolarization. Protein SK is suggested to modulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. Protein SK family consists of three subtypes termed SK1(KCa2.1), SK2(KCa2.2), and SK3(KCa2.3). SK channel, which is gated solely by intracellular calcium, contributes noticeably to the late phase of cardiac repolarization. And it can be blocked by apamin through similarity. Apamin-sensitive AHPs (afterhyperpolarization) seem to be derived from either SK2 or SK3 channel subunits. The SK channels provide a vital connection between changes in intracellular Ca2+ levels and membrane potentials.

Recent studies have demonstrated that protein SK plays a crucial role in cardiac repolarization in pathophysiological but not normal physiological conditions, which indicates the potential therapeutic value of protein SK for the treatment of cardiovascular diseases. Here show three small conductance calcium-activated potassium channel protein family members in human for your review.

Human Protein SK Members
KCNN1 KCNN2 KCNN3

Based on our Magic™ membrane protein production platform, scientists at Creative Biolabs are experienced in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

What’s more, our Magic™ membrane protein antibody discovery platform can assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

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