Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSmall conductance calcium-activated potassium channel protein (protein SK) family forms a voltage-independent potassium channel which is activated by intracellular calcium. And the activation is followed by membrane hyperpolarization. Protein SK is suggested to modulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. Protein SK family consists of three subtypes termed SK1(KCa2.1), SK2(KCa2.2), and SK3(KCa2.3). SK channel, which is gated solely by intracellular calcium, contributes noticeably to the late phase of cardiac repolarization. And it can be blocked by apamin through similarity. Apamin-sensitive AHPs (afterhyperpolarization) seem to be derived from either SK2 or SK3 channel subunits. The SK channels provide a vital connection between changes in intracellular Ca2+ levels and membrane potentials.
Recent studies have demonstrated that protein SK plays a crucial role in cardiac repolarization in pathophysiological but not normal physiological conditions, which indicates the potential therapeutic value of protein SK for the treatment of cardiovascular diseases. Here show three small conductance calcium-activated potassium channel protein family members in human for your review.
Based on our MemDX™ membrane protein production platform, scientists at Creative Biolabs are experienced in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, with the stable cell line.
What’s more, our MemDX™ membrane protein antibody discovery platform can assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
