Small conductance calcium-activated potassium channel protein (protein SK) family forms a voltage-independent potassium channel which is activated by intracellular calcium. And the activation is followed by membrane hyperpolarization. Protein SK is suggested to modulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. Protein SK family consists of three subtypes termed SK1(KCa2.1), SK2(KCa2.2), and SK3(KCa2.3). SK channel, which is gated solely by intracellular calcium, contributes noticeably to the late phase of cardiac repolarization. And it can be blocked by apamin through similarity. Apamin-sensitive AHPs (afterhyperpolarization) seem to be derived from either SK2 or SK3 channel subunits. The SK channels provide a vital connection between changes in intracellular Ca2+ levels and membrane potentials.
Recent studies have demonstrated that protein SK plays a crucial role in cardiac repolarization in pathophysiological but not normal physiological conditions, which indicates the potential therapeutic value of protein SK for the treatment of cardiovascular diseases. Here show three small conductance calcium-activated potassium channel protein family members in human for your review.
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