Solute carrier family 12 (SLC12) consists of nine genes encoding seven functionally identified members and two orphan transporters. They are membrane transporters with a proposed Kyte-Dolittle topology of a hydrophilic short amino-terminal and long carboxyl-terminal domain. Studies have shown that an important characteristic of the SLC12 family is that the activity of all members is regulated by the phosphorylation/dephosphorylation of key serine/threonine residues located at the amino- and carboxy-terminal domains. Based on the degree of identity, this family is divided into two branches. The first includes the Na⁺ -coupled chloride cotransporters, including the Na⁺ :K⁺ :2Cl⁻ cotransporters 1 and 2 (NKCC1 and NKCC2) and the Na⁺ :Cl⁻ cotransporter (NCC), exhibiting about 50% identity amongst each other. The second branch is K⁺ -driven and encompasses four genes encoding the K⁺: Cl⁻ cotransporters (KCC1 through KCC4), which exhibit about 70% identity.
Here, we have described in detail of members of the SLC12 family, including but not limited to SLC12A1, SLC12A2, SLC12A3, and SLC12A4. To learn more detailed information, please click the links below.
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