The human solute carrier (SLC) transporters are central targets for drug development. Solute carrier family 18, also known as vesicular monoamine transporters (VMATs), is a class of transport proteins integrated into the membrane of synaptic vesicles of presynaptic neurons. Solute carrier family 18 consists of four members in human, referred to as SLC18A1 (VMAT1, synaptic vesicular amine transporter), SLC18A2 (VMAT2, synaptic vesicular amine transporter), SLC18A3 (vesicular acetylcholine transporter, VAChT), SLC18B1 (MFS-type transporter SLC18B1). They function to transport monoamine neurotransmitters including dopamine, norepinephrine, serotonin, epinephrine, and histamine into the vesicles which release the neurotransmitters into synapses as chemical messages to postsynaptic neurons. Members of solute carrier family 18 use a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.
Members of solute carrier family 18 have possible applications for many conditions and have been regarded as the sites of action of therapeutical drugs, such as tetrabenazine and reserpine. The biological research of solute carrier family 18 includes hypertension, drug addiction, psychiatric disorders, Parkinson's disease, and other neurological disorders. Here are the three members of the solute carrier family 18.
By using our Magic™ membrane protein production platform, scientists at Creative Biolabs are well-experienced in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.
In addition, our Magic™ membrane protein antibody discovery platform can also be applied in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.