Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe concentrative nucleoside transporter family, SLC28, consists of three subtypes of sodium-dependent, concentrative nucleoside transporters, CNT1 (SLC28A1), CNT2 (also called the sodium-dependent purine nucleoside transporter SPNT, SLC28A2), and CNT3 (SLC28A3). These proteins are membrane-bound transporters that transport nucleosides and nucleoside analogs actively into cells by coupling transport to the inwardly directed sodium gradient. They transport both naturally occurring nucleosides and synthetic nucleoside analogs for the treatment of various diseases.
Although there is no known disease state associated with this family, these transporters play a role in the pharmacokinetics and pharmacodynamics of antineoplastic and antiviral nucleoside analogs due to their tissue localization and specificity for therapeutic nucleoside analogs. Early studies in isolated mammalian tissues and cell lines have shown that nucleoside uptake is characterized by low-affinity and high-affinity systems and that the high-affinity system(s) is active, concentrative, and Na+-dependent. The low-affinity system is now considered to be the equilibrative nucleoside transporter (ENT) family, SLC29, while SLC28 is responsible for high-affinity transport.
Here show three subtypes of SLC28 family, SLC28A1, SLC28A2, and SLC28A3, which differ in their substrate specificities. SLC28A1 is pyrimidine nucleoside preferring. CNT2 is purine-nucleoside preferring, and CNT3 transports both pyrimidine and purine nucleosides.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
