Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsThe solute carrier family 41 (SLC41) of vertebrate magnesium transporters was first identified and characterized in 2003. The family consists of three members - SLC41A1, SLC41A2, and SLC41A3. Members of the SLC41 transporter family are found in all eukaryotes, and Mg2+ transporters in vertebrate cells display distant homology to the prokaryotic MgtE family of Mg2+ transporters.
Fig.1 Mg2+ transporters in vertebrate cells. (Sahni, 2013)
SLC41A1 was the first member of the family to be described. High expression levels of SLC41A1 have been detected in the human heart and testis, while prostate, adrenal gland, skeletal muscle, and thyroid have lower expression levels. SLC41A1 acts as a non-specific divalent cation channel. The PARK16 (Parkinson disease 16) locus has been shown to carry mutations in patients of both European and Asian ancestries.
The second member of the SLC41 transporter family, SLC41A2, has now been identified in a large number of vertebrate species. SLC41A2 is expressed in normal human tissues with lymph nodes, skin, lungs, stomach, and testis. According to the database on the European Bioinformatics Institute (EBI) website, SLC41A2 is reported as either over or under expressed in 75 disease states including a number of carcinomas and lymphomas. Since both SLC41A1 and SLC41A2 have been shown to function as magnesium transporters, SLC41A3 is likely to play a similar functional role in vertebrates.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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