Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier organic anion transporters, also known as organic-anion-transporting polypeptides (OATPs) encoded by the SLCO genes, constitute an important transporter superfamily that mediates transmembrane transport of various endo- and xenobiotics (bile acids, bilirubin, steroid hormone conjugates, thyroid hormones, prostaglandins, clinically used drugs, and toxins). Twelve human OATPs with different transport functions are expressed in various tissues. The expression of some members shows a restricted pattern (OATP1B1/OATP1B3 in the liver, OATP4C1 in the kidney, and OATP6A1 in testis). Structurally, they are 12-transmembrane glycoproteins and contain many conserved structural features that are important for substrate transport. The most well-characterized human OATPs are OATP1A2, OATP1B1, OATP1B3, and OATP2B1. Very little is known about the function and characteristics of OATP5A1 and OATP6A1. Moreover, some OATPs, such as PATP1B3, are up-regulated in malignant tissues (colon, breast, prostate). Thus, they can act as biomarkers for many tumors and can be considered as important therapeutic targets in anti-cancer drug design.
Here, we give an introduction to the following human OATPs, summarizing our knowledge about OATP transport mechanisms, functions, protein structure, and pharmacology.
| Human Solute Carrier Organic Anion Transporter Family Members | |||
| SLCO1A2 | SLCO1B1 | SLCO1B3 | SLCO1B7 |
| SLCO1C1 | SLCO2A1 | SLCO2B1 | SLCO3A1 |
| SLCO4A1 | SLCO4C1 | SLCO5A1 | SLCO6A1 |
To strengthen our understanding of the structure and function of these membrane proteins, Creative Biolabs has provided our clients with comprehensive membrane protein preparation services. We can solubilize your interested protein using a variety of detergents. Based on our powerful detergent screening platform, we can always find an optimal match for your protein. Besides, we can also use alternative methods and approaches to reconstitute your proteins such as insertion into liposomes, bicelles, nanodiscs, lipoparticles, and polymers. Our work is based on many years of experience gained in a significant number of successful development projects. For more information, please see Magic™ membrane protein production platform.
Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform to prepare high-quality antibodies against these membrane protein targets. We adapt to your requirements by providing either individual service modules or fully comprehensive service. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
