Solute Carrier Organic Anion Transporter Family

Solute carrier organic anion transporters, also known as organic-anion-transporting polypeptides (OATPs) encoded by the SLCO genes, constitute an important transporter superfamily that mediates transmembrane transport of various endo- and xenobiotics (bile acids, bilirubin, steroid hormone conjugates, thyroid hormones, prostaglandins, clinically used drugs, and toxins). Twelve human OATPs with different transport functions are expressed in various tissues. The expression of some members shows a restricted pattern (OATP1B1/OATP1B3 in the liver, OATP4C1 in the kidney, and OATP6A1 in testis). Structurally, they are 12-transmembrane glycoproteins and contain many conserved structural features that are important for substrate transport. The most well-characterized human OATPs are OATP1A2, OATP1B1, OATP1B3, and OATP2B1. Very little is known about the function and characteristics of OATP5A1 and OATP6A1. Moreover, some OATPs, such as PATP1B3, are up-regulated in malignant tissues (colon, breast, prostate). Thus, they can act as biomarkers for many tumors and can be considered as important therapeutic targets in anti-cancer drug design.

Here, we give an introduction to the following human OATPs, summarizing our knowledge about OATP transport mechanisms, functions, protein structure, and pharmacology.

Human Solute Carrier Organic Anion Transporter Family Members

To strengthen our understanding of the structure and function of these membrane proteins, Creative Biolabs has provided our clients with comprehensive membrane protein preparation services. We can solubilize your interested protein using a variety of detergents. Based on our powerful detergent screening platform, we can always find an optimal match for your protein. Besides, we can also use alternative methods and approaches to reconstitute your proteins such as insertion into liposomes, bicelles, nanodiscs, lipoparticles, and polymers. Our work is based on many years of experience gained in a significant number of successful development projects. For more information, please see Magic™ membrane protein production platform.

Magic™ membrane protein production platform – Creative Biolabs

Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform to prepare high-quality antibodies against these membrane protein targets. We adapt to your requirements by providing either individual service modules or fully comprehensive service. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: UK - Germany
Call us at:
USA: 1-631-381-2994
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us