Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAs a leading service provider in the field of cancer immunotherapy, Creative Biolabs now presents one-stop antagonistic antibody development service for both research and therapeutic applications. Particularly, we offer a broad range of early development service, especially for antagonistic antibody design and engineering. Here, we are happy to introduce our antagonistic antibody development service for the treatment of squamous cell carcinoma of the head and neck.
SCCHN is one of the most common cancers worldwide, with incidences of more than 30 per 100 000 population. It encompasses a variety of tumors originating in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx or larynx with the difference in epidemiology, etiology and therapeutical approach. As a number of the immunosuppressive group of diseases that employ different immune evasion mechanisms, SCCHN has been demonstrated to be implicated in carcinogenesis of human papillomavirus (HPV)-positive oropharyngeal cancer. In addition, risk factors for SCCHN include cigarette, cigar, or pipe smoking and excessive alcohol consumption. Generally, multimodality therapeutic approach is employed for SCCHN patients with locally advanced disease. For recurrent/metastatic (R/M) disease, cytotoxic-based chemotherapy remains the standard therapeutic option.
Fig.1 Mechanism of PD-1/PD-L1 blockade. (von der Grün, 2019)
Recently, growing efforts have been paid to identify suitable targets for immunity stimulation, not only by blocking negative regulatory pathways in effector lymphocytes but also by enhancing co-stimulatory signals. The receptor-ligand interplay between PD-1 and its receptors is particularly noteworthy. Studies have shown that both ligands of PD-1, namely PD-L1 and PD-L2, are overexpressed in SCCHN and naturally induced by pro-inflammatory signals, protecting self-tissue from an excessive immune response. Binding of PD-L1 and PD-L2 could active PD-1 and thus inhibit the T-cell receptor (TCR) downstream pathway via tyrosine phosphatase SHP-2 activity, which provides a new powerful tool in anticancer therapy with the potential to reverse cancer-mediated immunosuppression. To date, several antibodies against PD-1 (pembrolizumab, nivolumab) and PD-L1 (atezolizumab, durvalumab, avelumab) have already been approved access to the market for various tumor entities. Most importantly, we are capable of antagonistic antibody development service for SCCHN therapy.
Creative Biolabs is dedicated to enabling you to free up your time for core work and project. Our service can be designed to meet your special needs if you have any requirements. If you are interested in our service, please feel free to contact us and our team will get back to you as soon as possible.
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