Introduction of SSTR1
Somatostatin receptor type 1 (SSTR1) is a protein that in humans is encoded by the SSTR1 gene. It is a novel EBV-associated promoter hypermethylation gene in gastric cancer. SSTR1 has an important tumour suppressive role in gastric cancer by modulating the expression of the important effectors involved in the regulation of cell proliferation, apoptosis, cell cycle and invasion. Epigenetic silencing of SSTR1 by EBV infection may contribute to the pathogenesis of EBV-associated gastric cancer.
|Basic Information of SSTR1|
|Aliases||SS-1-R,SS1-R, SS1R, SRIF-2|
|Organism||Homo sapiens (Human)|
Function of SSTR1 Membrane Protein
SSTR1 is a receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. It stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins. Besides, studies have revealed that SSTR1 and SSTR2 were highly expressed in the medial preoptic area, suprachiasmatic nucleus, as well as the arcuate nucleus. However, high SSTR1, but low SSTR2, expression was found in the para- and periventricular nuclei as well as in the ventral premammillary nucleus. Therefore, these distributional patterns conform to those of somatostatin binding sites as visualized by in vitro autoradiography, revealing that an essential proportion of SSTR1 and SSTR2 receptors in the hypothalamus are associated with the perikary and dendrites of intrinsic neurons.
Fig.1 Rat sst1 receptor interactions and phosphorylation sites. (Csaba, 2012)
Application of SSTR1 Membrane Protein in Literature
This article reports that SSTR1 is a novel methylated gene driven by EBV infection in gastric cancer cells and acts as a potential tumour suppressor.
This article reveals that SSTR1 is a member of a larger family of somatostatin receptors.
Authors in this group demonstrate that sst transcripts are expressed and functional in cultured retroorbital fibroblasts.
This article reveals that potent SSTR1-selective agonists could have a therapeutic role in Medullary thyroid carcinoma (MTC).
This article suggests the presence, even if at different concentrations, of all SSTR1-5 receptors in retroorbital lymphocytes from Graves' ophthalmopathy (GO), shows that they are targeted by SST analogs and could explain the effects described in GO patients treated with SST analogs.
SSTR1 Preparation Options
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