PRODUCTS

Online Inquiry

For Research Use Only. Not For Clinical Use.

STEMOD™ iPSC-derived AD Disease Model (APP, ΔE693)(MoCNS-WQ004)

Datasheet

Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities. This disease cell model has a mutation (E693delta) on APP gene , belongs to family FAD, a familial early-onset form of Alzheimer disease. Generating pluripotent stem cells from fibroblasts, then differentiate into neurons . This disease cell model provides a platform to explore disease mechanisms in AD.

Specifications
Organ System Central Nervous System
Disease Alzheimer's Disease (AD)
Target Gene APP
Gene Function Encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.
Mutation ΔE693
Phenotype Extra- and intracellular Aβ40 and Aβ42 strongly decreased
Source Fibroblasts
Cellular Assays Immunocytochemistry, Immunoblots, Electrochemiluminescence Assays, Bisulfite Genomic Sequencing, Microarray Analysis for iPSCs
Target Gene
Gene ID 351
Uniprot ID P05067

For Research Use Only. Not For Clinical Use.

Related Products