Creative Biolabs has been committed to bringing together highly skilled
experts with varied backgrounds applicable to cell therapy research and
development. Each of our experts plays a key role in advancing our clients' manufacturing
processes and delivering exceptional results. We have extensive expertise in
all aspects of cell therapy research and our extensive range of assays and
services support cell therapy development. We offer both routine and custom
designed assays that are regulatory compliant to ensure the safety, purity, and
efficacy of your drug product. In addition, we are committed to providing high
quality, GMP-compliant testing at all steps of your drug development program.
At Creative Biolabs, we enhance your research and data
relevancy by acquiring and reprogramming induced
pluripotent stem cells (iPSC) from a specific patient
clinical profile. We have developed streamed-line protocols for efficient iPSC
generation with viral vectors, DNA (plasmid), RNA and recombinant proteins.
Creative Biolabs also provides IPSC maintenance services and large-scale pluripotent cell production in both 2D and 3D formats. In addition, pluripotent characterization assays and custom genome editing
services in human cells,
including cell lines and patient-derived cells are also available. Creative
Biolabs has extensive expertise in iPSC
differentiation and can provide the
most flexible, adaptable, and customizable solutions for your project.
Mesenchymal stem cells (MSCs) are adult stem cells
traditionally found in the bone marrow. However, mesenchymal stem cells can
also be isolated from other tissues including cord blood, peripheral blood,
fallopian tube, and fetal liver and lung. Just like other stem cell types, MSCs
have a high capacity for self-renewal while maintaining multipotency. Thus,
mesenchymal stem cells have an enormous therapeutic potential for tissue repair
and have been shown to be capable of differentiating into multiple cell types
including adipocytes, chondrocytes, osteocytes, and cardiomyocytes.
The ability of MSCs to differentiate into bone, fat, or
cartilage has shown promise in the fields of bioengineering and tissue
regeneration. Creative Biolabs offers products designed to identify the
progression of MSCs into osteogenic, adipogenic, muscular, and chondrogenic
lineages, which have many advantages over the traditional model. We provide MSC isolation and expansion, characterization and differentiation services to support your basic research and regenerative
biology initiatives. Please contact Creative Biolabs' technical support to
learn more about MSCs.
The shortage of available organs for transplantation is
the major obstacle hindering the application of regenerative medicine and has
also become a desperate problem faced by more and more patients nowadays. The
recent development and application of the 3D bioprinting technique in biological research has revolutionized the tissue
engineering methods, and become a promising solution for tissue regeneration.
Creative Biolabs is your partner in establishing 3D printing platform. Creative Biolabs offers you a universal hydrogel
bio-ink, which is available to be used across all 3D bioprinting instruments.
With our cell ink, you have the ability to accurately bio-fabricate
biologically relevant 3D tissues and organs which are essential to achieving
life-like function. Our bio-ink offers a 3D platform that can manipulate stem
cells into, potentially, any cell type, allowing the design of patient-specific
therapies, whereby autologous stem cells can be used to aid tissue self-repair
and treat disease. The key applications of the 3D tissue include use in
high-throughput in vitro screening for toxicology and drug discovery,
organoids, tissue engineering and regenerative medicine.
Human pluripotent stem cells provide a versatile
platform for regenerative studies, drug testing, and disease modeling. Creative
Biolabs offers genome-editing systems based on transcription activator-like effectors (TALEs), and an RNA-guided
DNA-specific nuclease, Cas9, that utilizes clustered regularly interspaced
short palindromic repeats (CRISPR). We also provide recombinant-based technology to support genome editing development for stem cells.
Fig.3 Application of genome editing in molecular
medicine (gene therapy, disease modeling). (Vasileva, 2015)
Creative Biolabs has developed assay services for gene
& cell therapy products. We have the expertise and directly relevant
experience to develop, validate, and perform your cell therapy related assays.
With our business operating expertise, we are guaranteed to develop proprietary
assays, including genetic/epigenetic
analysis, using both in vivo and in vitro models, to better predict human outcomes. At any point along your product
development path, Creative Biolabs' Assay Services can help you with immediate
support for specific biological assay development.
Why Choose Us?
Creative Biolabs has over ten years of experience in
normal human cells and best-in-class cGMP compliance. We are an industry leader
in development, manufacturing and assay services for cell-based therapeutics.
Our process development scientists work with our customers to develop client-specific
custom protocols. We cater to every unique need, covering all aspects of the
business. And we fully understand the need for isolating projects and are very
careful to protect our client's product and process. Please feel free to
contact us for further information or requests.
Creative Biolabs offers custom products, contract manufacturing, and
analytical services that enable global biotechnology, pharmaceutical, and
contract research organizations to respond efficiently to the rapidly changing
research and development. For cell therapy manufacturing, Creative Biolabs
works with our customers to overcome any quality, regulatory, or security
challenges. We are the premier partner to accelerate market entry. Contact us today to discuss your cell-therapy project with a technical specialist. After
discussing the details of your project, we can provide a price quote for your
Vasileva, E.A.; et al. Genome-editing tools
for stem cell biology. Cell Death Dis. 2015, 6: e1831.