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For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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Basic Research Services


Creative Biolabs has been committed to bringing together highly skilled experts with varied backgrounds applicable to cell therapy research and development. Each of our experts plays a key role in advancing our clients’ manufacturing processes and delivering exceptional results. We have extensive expertise in all aspects of cell therapy research and our extensive range of assays and services support cell therapy development. We offer both routine and custom designed assays that are regulatory compliant to ensure the safety, purity, and efficacy of your drug product. In addition, we are committed to providing high quality, GMP-compliant testing at all steps of your drug development program.

Cell-based therapy – Creative Biolabs

Induced Pluripotent Stem Cells (iPSC) Service

At Creative Biolabs, we enhance your research and data relevancy by acquiring and reprogramming induced pluripotent stem cells (iPSC) from a specific patient clinical profile. We have developed streamed-line protocols for efficient iPSC generation with viral vectors, DNA (plasmid), RNA and recombinant proteins. Creative Biolabs also provides IPSC maintenance services and large-scale pluripotent cell production in both 2D and 3D formats. In addition, pluripotent characterization assays and custom genome editing services in human cells, including cell lines and patient-derived cells are also available. Creative Biolabs has extensive expertise in iPSC differentiation and can provide the most flexible, adaptable, and customizable solutions for your project.

Mesenchymal Stem Cells (MSCs) Service

Mesenchymal stem cells (MSCs) are adult stem cells traditionally found in the bone marrow. However, mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Just like other stem cell types, MSCs have a high capacity for self-renewal while maintaining multipotency. Thus, mesenchymal stem cells have an enormous therapeutic potential for tissue repair and have been shown to be capable of differentiating into multiple cell types including adipocytes, chondrocytes, osteocytes, and cardiomyocytes.

The ability of MSCs to differentiate into bone, fat, or cartilage has shown promise in the fields of bioengineering and tissue regeneration. Creative Biolabs offers products designed to identify the progression of MSCs into osteogenic, adipogenic, muscular, and chondrogenic lineages, which have many advantages over the traditional model. We provide MSC isolation and expansion, characterization and differentiation services to support your basic research and regenerative biology initiatives. Please contact Creative Biolabs’ technical support to learn more about MSCs.

Organoid and 3D Bioprinting Service

The shortage of available organs for transplantation is the major obstacle hindering the application of regenerative medicine and has also become a desperate problem faced by more and more patients nowadays. The recent development and application of the 3D bioprinting technique in biological research has revolutionized the tissue engineering methods, and become a promising solution for tissue regeneration.

3D Bioprinting – Creative Biolabs

Creative Biolabs is your partner in establishing 3D printing platform. Creative Biolabs offers you a universal hydrogel bio-ink, which is available to be used across all 3D bioprinting instruments. With our cell ink, you have the ability to accurately bio-fabricate biologically relevant 3D tissues and organs which are essential to achieving life-like function. Our bio-ink offers a 3D platform that can manipulate stem cells into, potentially, any cell type, allowing the design of patient-specific therapies, whereby autologous stem cells can be used to aid tissue self-repair and treat disease. The key applications of the 3D tissue include use in high-throughput in vitro screening for toxicology and drug discovery, organoids, tissue engineering and regenerative medicine.

Genome Editing Services for Stem Cell

Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing, and disease modeling. Creative Biolabs offers genome-editing systems based on transcription activator-like effectors (TALEs), and an RNA-guided DNA-specific nuclease, Cas9, that utilizes clustered regularly interspaced short palindromic repeats (CRISPR). We also provide recombinant-based technology to support genome editing development for stem cells.

Fig.3 Application of genome editing in molecular medicine (gene therapy, disease modeling). (Vasileva, 2015) iPCSs could be generated from somatic cells of the patient with monogenic diseases for correction, differentiation into cell types suitable for therapy and transplantation into a patient to restore the function.

Assay Development Service

Creative Biolabs has developed assay services for gene & cell therapy products. We have the expertise and directly relevant experience to develop, validate, and perform your cell therapy related assays. With our business operating expertise, we are guaranteed to develop proprietary assays, including genetic/epigenetic analysis, using both in vivo and in vitro models, to better predict human outcomes. At any point along your product development path, Creative Biolabs' Assay Services can help you with immediate support for specific biological assay development.

Why Choose Us?

Creative Biolabs has over ten years of experience in normal human cells and best-in-class cGMP compliance. We are an industry leader in development, manufacturing and assay services for cell-based therapeutics. Our process development scientists work with our customers to develop client-specific custom protocols. We cater to every unique need, covering all aspects of the business. And we fully understand the need for isolating projects and are very careful to protect our client's product and process. Please feel free to contact us for further information or requests.

Creative Biolabs offers custom products, contract manufacturing, and analytical services that enable global biotechnology, pharmaceutical, and contract research organizations to respond efficiently to the rapidly changing research and development. For cell therapy manufacturing, Creative Biolabs works with our customers to overcome any quality, regulatory, or security challenges. We are the premier partner to accelerate market entry. Contact us today to discuss your cell-therapy project with a technical specialist. After discussing the details of your project, we can provide a price quote for your project.

Reference

  1. Vasileva, E.A.; et al. Genome-editing tools for stem cell biology. Cell Death Dis. 2015, 6: e1831.

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  • 45-1 Ramsey Road, Shirley, NY 11967, USA
  • Tel: 1-631-381-2994
  • Fax: 1-631-207-8356
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Europe

  • Heidenkampsweg 58, 20097 Hamburg, Germany
  • Tel: 44-207-097-1828
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