For Lab Research Use Only, Not for Human or Animal Therapeutic Use.
disease is a rising burden for society and finance in aging societies, impacting
approximately 1 billion individuals around the world, especially regarding
neurodegenerative diseases including dementia, Alzheimer’s disease (AD), and
Parkinson’s diseases (PD). The molecular basis of most neurodegenerative
diseases is not fully understood till now, and the study of neurological disorders is particularly challenging. The
emerging technology of iPSC attracts attention worldwide, giving access to
genetic/epigenetic mechanism studies and new drug/methods exploration of
neurodegenerative disease by generating patient-specific disease models in vitro. Creative Biolabs provides a series
of patient-specific iPSC models of genetically inherited neurological diseases,
which will satisfy different research demands for worldwide clients.
Together with gene editing techniques to reprogram human
somatic cell into iPSC and differentiate iPSC into neurons, iPSC-based
neurological disease models have revolutionized the utility of human in vitro models of
neurological disease in the past decade, contributing to molecular/pathological
mechanisms understanding, early diagnosis, drug discovery/screening as well as
personalized precision medicine. Experienced ability is critical for generating
iPSC-based models, including generating, expanding and purifying functional and
disease-relevant neurological cells.
Steps of hPSC-based Disease Models
Determining an appropriate disease target or mutation
Directing hPSC differentiation into disease/phenotype-relevant cell populations
Identifying and purifying disease-relevant cells
Neurological Lineages Differentiation of hPSCs
somatic cells like fibroblasts and other peripheral cells are collected and
reprogramed into human pluripotent stem cells (hPSCs). Differentiation of hPSCs
is regulated by particular cellular factors, mainly belonging to four signaling
pathways (BMP, FGF, WNT/β-catenin and TGF-β/activin/nodal). Thus far, hPSCs
have been successfully differentiated into cortical neurons, DA neurons, motor
neurons, astrocyte, Purkinje cell, neural
progenitor cells (NPCs) as well as neural stem cells (NSCs) by researchers
around the world.
Fig 1. Directed Neural Differentiation of Human
Pluripotent Stem Cells.
Features of Nervous System
Rich experiences in iPSC reprogramming
A biologically relevant culture environment for iPSCs
Standardized operation protocol
Differentiated neurons highly relevant to disease phenotype
Best after-sale services
hPSC Models of Neurological Diseases
(hPSC-NU) models of inherited neurological diseases are used to investigate neurological
disease pathology mechanism and evaluate new medical methods and drugs. Creative
Biolabs has established a state-of-the-art STEMODTM neurological
disease models platform, to offer a list of hPSC-UN models with accurate
evaluated neurological disease phenotypes. Those models are prepared for the
investigation of Alzheimer’s disease, Parkinson’s disease and other inherited neurodegenerative disorders.
Please feel free to contact us if you don’t find
the proper neurological disease models for your research. Customized service
will also be provided to meet every specific demand!