The in vitro organoid system is a significant technological breakthrough that has already been acknowledged as a critical tool in a variety of basic biological research and clinical applications. This near-physiological three-dimensional (3D) model promotes an accurate study of a range of in vivo physiology processes, such as tissue renewal, stem cell functions and tissue responses to mutation, damage, or drugs. As a top-class institution as well as experienced supplier in biotech markets, Creative Biolabs has achieved quantities of challenging cases for customers and won great reputations among global users. We are pleasure to offer cell-based organoid services for cell therapies with many different cell lineages to satisfy clients' special needs.
Organoid has historically been described to encompass all 3D organotypic cultures originated from primary tissues (either single cells or tissue subunits), embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs), established cell lines, and whole or segmented organs (e.g. organ explants composed by multiple tissue types). Now, this technology is defined as a cell-derived in vitro 3D model, capable of self-renewal and self-organization, and exhibits similar organ functionality as the tissue of origin. Organoid mimicking different tissues or organs has been successfully produced from human patients and animal models and this culture system represents the native physiology of cells in vivo.
Fig.1 Organoid generation and culture from primary tissue and ESCs/iPSCs. (Fatehullah, 2016)
Examine tissue morphogenesis and organ development
Build up in vitro disease models
Drug testing for sensitivity and toxicity
Potentially form complex tissues/organs for transplantations
Fig.2 Applications of organoid technology for studying development, homeostasis and diseases. (Fatehullah, 2016)
Organoids have currently being employed in many biomedical aspects. The value of this technique for disease modeling and therapy development is increasingly apparent. For instance, brain organoids have been used to imitate neurodegenerative and psychiatric diseases. In cancer research, tumor heterogeneity, progression, and evolution have been explored by the patient-derived liver and colorectal cancer organoid. Finally, individual drug responses can also be investigated, as shown in mammary and colorectal tumors.
There are several predominant advantages of organoid engineering summarized as below.
Reproduce for a long time without genomic alterations
Limited amounts of starting materials can be used for wide applications
Expanded for numerous applications
Amenable to a broad range of established experimental technologies
The possibility of generating isogenic tissues for human transplantation in regenerative medicine
Organoid Service in Creative Biolabs
Organoid is a newly-developing tool for cell therapy that enhances the modeling of human development and disease since only requiring a small number of cells to form a large range of tissue types. In Creative Biolabs, we are equipped with skillful staff and years of service experience so that experiments can be easily controlled by pure cultures of specific tissues whilst advances in bioengineering mean exact modeling, reflecting complex procedures.
Besides, we would like to introduce the following platforms regarding organoids, in order to solve your issues.
Cerebral Organoid Service
Thyroid Organoid Service
Thymic Organoid Service
Hepatic Organoid Service
Pancreatic Organoid Service
Gut Organoid Service
Intestinal Organoid Service
Gastric Organoid Service
Lingual Organoid Service
Epithelial Organoid Service
Lung Organoid Service
Kidney Organoid Service
Cardiac Organoid Service
Organoid as an advanced system is being developed at a rapid step and has positive implications in clinical trials and academic studies. If you are interested in related cell therapies or one-stop, customized services provided by Creative Biolabs, please contact us for more information.
1.Fatehullah, A.; et al. Organoids as an in vitro model of human development and disease. Nat Cell Biol. 2016, 18(3): 246-254.