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For Research Use Only. Not For Clinical Use.

STEMOD™ iPSC-derived PD Disease Model (SNCA, SNCA_Tri)(MoCNS-WQ008)

Datasheet

Parkinson disease is a slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients. This disease cell model has a triplication of the SNCA genomic locus. Generating pluripotent stem cells from fibroblasts, then differentiate into DA neurons . This disease cell model provides a platform to explore disease mechanisms in PD.

Specifications
Organ System Central Nervous System
Disease Parkinson Disease (PD)
Target Gene SNCA
Gene Function SNCA may serve to integrate presynaptic signaling and membrane trafficking.
Mutation SNCA_Tri
Phenotype Elevated levels of α-Syn protein, decreased GABAergic
and dopaminergic neurons differentiation, decreased neurite outgrowth
and impaired electrophysiology compared to controls.
Source Fibroblasts
Cellular Assays Immunofluorescence, Real-time PCR analysis, Immunoblot analysis, Electrophysiology, Neurite tracing
Target Gene
Gene ID 6622
Uniprot ID P37840

For Research Use Only. Not For Clinical Use.

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