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STEMOD™ Disease Models


STEMOD™ Disease Models

The critical component in studying the pathophysiology and etiology of human disease is the requirement of a physiologically relevant experimental disease model that faithfully recapitulates the respective clinical manifestations and pathophysiology. The ground-breaking development of induced pluripotent stem cell (iPSC) technology provides investigators with a self-renewing and unlimited source of pluripotent cells for targeted differentiation and human diseases modeling. The increasingly refined abilities to differentiate iPSCs into disease-relevant target cells have deep implications for identifying disease-causing genes, understanding disease pathophysiology, and developing more precise therapeutics. Creative Biolabs provides a series of patient-specific iPSC models of human diseases for different research demands of worldwide clients.

At the STEMODTM disease model platform, we offer the high-quality and customized iPSC services to generate the physiologically relevant disease models that help our clients understand the etiology and progression of a diverse array of diseases, involving cardiovascular system, nervous system, ocular system, etc. Based on advanced technology and years of research, Creative Biolabs is able to provide a side-by-side comparison of human iPSC based in vitro and in vivo experimental models to synergistically accelerate the elucidation of the pathophysiology mechanisms in basic research, and safety pharmacology. Various iPSC-derived models and relevant assay systems have been established in-house, which greatly facilitate to investigate the underlying disease mechanisms and evaluate therapeutic options in a patient-specific manner. In addition, a series of stringent criteria are applied to implement quality control of iPSC-derived models in order to guarantee reliability and expedite their IND application.

Patient-specific pharmacotherapy using iPSC Fig 1. Patient-specific pharmacotherapy using iPSC. (Li, 2017)

As a frontier biotech service provider, we are glad to share our valuable experience in iPSC-based disease modeling. Our STEMODTM disease modeling platform provides a range of iPSC models with accurate evaluated cell phenotypes, which are prepared for various disease types including human neural disorders, cardiac diseases, and other genetic disorders. Scientists of Creative Biolabs will work with you to design the program that best fits your requirements and advance the clinical trials. At the same time, the relevant evaluation assays either in vivo or in vitro can be designed according to your targets and downstream applications. Please feel free to contact us to learn more about our capabilities and services.

References

  1. Doss, M. and Sachinidis, A. (2019). Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications. Cells, 8(5), p.403.
  2. Singh, V.; et al. (2015). Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Frontiers in Cell and Developmental Biology, 3.
  3. Li, Y.; et al. (2017). Patient-Specific Induced Pluripotent Stem Cell-Based Disease Model for Pathogenesis Studies and Clinical Pharmacotherapy. Circulation: Arrhythmia and Electrophysiology, 10(6).

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